Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study

Azuhata, Takeo; Hayakwa, Mineji; Maekawa, Kunihiko; Komatsu, Tomohide; Kuwana, Tsukasa; Kawano, Daisuke; Nakamura, Kazuhiro; Kinoshita, Kosaku; Wada, Takeshi; Tanjoh, Katsuhisa

Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study

Azuhata, Takeo; Hayakwa, Mineji; Maekawa, Kunihiko et al.

Clinical and applied thrombosis/hemostasis, 2020, 26, UNSP 1076029620912827

Permalink : https://hdl.handle.net/2115/78419

このアイテムのアクセス数:696件（2026-08-10 20:55 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1177/1076029620912827			27

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/78419
タイトル	Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study
著者	Azuhata, Takeo ; Hayakwa, Mineji ; Maekawa, Kunihiko ; Komatsu, Tomohide ; Kuwana, Tsukasa ; Kawano, Daisuke ; Nakamura, Kazuhiro ; Kinoshita, Kosaku ; Wada, Takeshi ; Tanjoh, Katsuhisa
著者名 Azuhata, Takeo
著者名 Hayakwa, Mineji
著者名 Maekawa, Kunihiko
著者名 Komatsu, Tomohide
著者名 Kuwana, Tsukasa
著者名 Kawano, Daisuke
著者名 Nakamura, Kazuhiro
e-Rad_Researcher 90260968 著者名 Kinoshita, Kosaku
e-Rad_Researcher 30455646 著者名 Wada, Takeshi
著者名 Tanjoh, Katsuhisa
言語	英語
キーワード	antithrombin
	disseminated intravascular coagulation
	mortality
	prognosis
	sepsis
発行日	2020-04-10
出版者	SAGE Publications
収録物名	Clinical and applied thrombosis/hemostasis
巻(号)	26
ページ	UNSP 1076029620912827
抄録	Supernormal antithrombin (AT) activity is rare in patients with sepsis. This study compared mortality rate of patients with sepsis and supernormal AT activity with that of other patients. This retrospective study included patients with sepsis from 42 intensive care units (ICUs) in Japan. Patients were included if their AT activity was measured on ICU admission, and if they did not receive AT concentrate. They were categorized into low, normal, and supernormal with respective AT activity of <= 70%, >70% to <= 100%, and >100%. The primary outcome was hospital in-patient mortality. Nonlinear regression analysis showed that mortality risk gradually increased with AT activity in the supernormal range, but without statistical significance. Survival rate was significantly lower in low (67%) and supernormal (57%) AT groups than in the normal AT group (79%; P < .001 and P = .008, respectively). After adjusting for disease severity and AT activity on day 2, supernormal AT activity was the only independent predictor of mortality. Sepsis with supernormal AT activity associated with high mortality, independent of disease severity, might be a predictor of in-hospital mortality.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	1076-0296
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1177/1076029620912827