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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/78446
タイトル	Involvement of Peptide Epimerization in Poly-gamma-glutamic Acid Biosynthesis
著者	Ogasawara, Yasushi ; Shigematsu, Mayuko ; Sato, Shota ; Kato, Hinata ; Dairi, Tohru
e-Rad_Researcher 20732986 著者名 Ogasawara, Yasushi
著者名 Shigematsu, Mayuko
著者名 Sato, Shota
著者名 Kato, Hinata
e-Rad_Researcher 70264679 著者名 Dairi, Tohru
言語	英語
発行日	2019-06-07
出版者	American Chemical Society
収録物名	Organic letters
巻(号)	21(11)
ページ	3972-3975
抄録	Poly-gamma-glutamic acid (PGA) is a promising polymer that comprises D- and L-glutamic acid (Glu) connected via an amide bond. PGA is biosynthesized by a transmembrane enzyme complex composed of PgsB, PgsC, and PgsA. However, the detailed reaction, especially the mechanism for introducing D-Glu residues into PGA, remains elusive. We herein report isotope tracer experiments with deuterated L- and D-Glu and demonstrate that epimerization of a growing peptide is involved in PGA biosynthesis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b01121.
PISSN	1523-7060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.orglett.9b01121

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