Spirulina Lipids Alleviate Oxidative Stress and Inflammation in Mice Fed a High-Fat and High-Sucrose Diet

Yang, Yuhong; Du, Lei; Hosokawa, Masashi; Miyashita, Kazuo

Spirulina Lipids Alleviate Oxidative Stress and Inflammation in Mice Fed a High-Fat and High-Sucrose Diet

Yang, Yuhong; Du, Lei; Hosokawa, Masashi et al.

Marine drugs, 2020, 18(3), 148

Permalink : https://hdl.handle.net/2115/78496

このアイテムのアクセス数:617件（2026-10-07 18:27 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/md18030148			51

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/78496
タイトル	Spirulina Lipids Alleviate Oxidative Stress and Inflammation in Mice Fed a High-Fat and High-Sucrose Diet
著者	Yang, Yuhong ; Du, Lei ; Hosokawa, Masashi ; Miyashita, Kazuo
著者名 Yang, Yuhong
著者名 Du, Lei
e-Rad_Researcher 10241374 著者名 Hosokawa, Masashi
e-Rad_Researcher 10182015 著者名 Miyashita, Kazuo
言語	英語
キーワード	Spirulina lipids
	gamma-linolenic acid
	carotenoids
	oxidative stress
	inflammation
発行日	2020-03
出版者	MDPI
収録物名	Marine drugs
巻(号)	18(3)
ページ	148
抄録	High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) and then their effects on oxidative stress and inflammation in the mice fed a HFHSD were investigated. The results show that the major lipid classes and fatty acid profiles of SLC and SLE were almost similar, but the gamma-linolenic acid (GLA) and carotenoid contents in SLE was a little higher than that in SLC. Dietary 4% SLC or SLE for 12 weeks effectively decreased the hepatic lipid hydroperoxide levels as well as increased the activities and mRNA levels of antioxidant enzymes in the mice fed a HFHSD. In addition, supplementation with SLC and SLE also markedly decreased the levels of serum pro-inflammatory cytokines and the mRNA expression of pro-inflammatory cytokines in the liver and epididymal white adipose tissue of mice fed a HFHSD, and the effects of SLC and SLE were comparable. These findings confirm for the first time that dietary Spirulina lipids could alleviate HFHSD-induced oxidative stress and inflammation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1660-3397
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/md18030148