Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra

Li, Wen; Kobayashi, Taishi; Moroi, Syoichi; Kotake, Hiroki; Ikoma, Tomokazu; Saeki, Hiroki; Ura, Kazuhiro; Takagi, Yasuaki

Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra

Li, Wen; Kobayashi, Taishi; Moroi, Syoichi et al.

Carbohydrate Polymers, 2019, 214, 303-310

Permalink : https://hdl.handle.net/2115/78551

このアイテムのアクセス数:745件（2026-08-18 05:53 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/78551
タイトル	Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra
著者	Li, Wen ; Kobayashi, Taishi ; Moroi, Syoichi ; Kotake, Hiroki ; Ikoma, Tomokazu ; Saeki, Hiroki ; Ura, Kazuhiro ; Takagi, Yasuaki
著者名 Li, Wen
著者名 Kobayashi, Taishi
著者名 Moroi, Syoichi
著者名 Kotake, Hiroki
著者名 Ikoma, Tomokazu
e-Rad_Researcher 90250505 著者名 Saeki, Hiroki
e-Rad_Researcher 90360940 著者名 Ura, Kazuhiro
e-Rad_Researcher 10212002 著者名 Takagi, Yasuaki
言語	英語
キーワード	Skate
	Processing waste
	Chondroitin sulfate
	Lipase
	Adipocyte
	High-fat diet mice model
発行日	2019-06-15
出版者	Elsevier
収録物名	Carbohydrate Polymers
巻(号)	214
ページ	303-310
抄録	We aimed to investigate the anti-obesity effects of chondroitin sulfate (CS) oligosaccharides obtained from cartilage of the skate Raja pulchra and to compare them with those of CSs of other molecular weights (MWts) (skate CS polysaccharides) and origins (shark CS, bovine CS). CSs suppressed pancreatic lipase activity as well as proliferation and lipid accumulation in mature adipocytes. Higher MWt CS had a greater lipase inhibitory activity than lower MWt CS. CSs of different origin show differing potencies for lipase inhibition and effects on adipocytes. Also, dietary intake of skate CS oligosaccharides could ameliorate obesity in high-fat diet mice model: it prevented gaining in body weight, liver weight and adipose tissue weight, maintained lower food consumption, inhibited intestinal absorption of triglyceride, and adjusted the serum endotoxin level. In conclusion, skate CS oligosaccharides have an anti-obesity activity, and the MWt and origin of the CSs may affect this activity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0144-8617
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.carbpol.2019.03.025