Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Noriyuki, Nagata; Hiroshi, Ohta; Nozomu, Yokoyama; Teoh, Yong B.; Nisa, Khoirun; Sasaki, Noboru; Osuga, Tatsuyuki; Morishita, Keitaro; Takiguchi, Mitsuyoshi

Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Noriyuki, Nagata; Hiroshi, Ohta; Nozomu, Yokoyama et al.

Journal of Veterinary Internal Medicine, 2020, 34(2), 659-668

Permalink : https://hdl.handle.net/2115/78602

このアイテムのアクセス数:628件（2026-08-16 20:10 集計）

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https://doi.org/10.1111/jvim.15720			36

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アクセス権	open access
URI	https://hdl.handle.net/2115/78602
タイトル	Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy
著者	Noriyuki, Nagata ; Hiroshi, Ohta ; Nozomu, Yokoyama ; Teoh, Yong B. ; Nisa, Khoirun ; Sasaki, Noboru ; Osuga, Tatsuyuki ; Morishita, Keitaro ; Takiguchi, Mitsuyoshi
著者名 Noriyuki, Nagata
著者名 Hiroshi, Ohta
著者名 Nozomu, Yokoyama
著者名 Teoh, Yong B.
著者名 Nisa, Khoirun
著者名 Sasaki, Noboru
著者名 Osuga, Tatsuyuki
著者名 Morishita, Keitaro
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	canine
	CCECAI
	chronic enteropathy
	CIBDAI
	clinical disease
	immunosuppressant
	intestinal lymphangiectasia
	ultralow-fat diet
発行日	2020-03
出版者	John Wiley & Sons
収録物名	Journal of Veterinary Internal Medicine
巻(号)	34(2)
ページ	659-668
抄録	Background In dogs with protein-losing enteropathy (PLE), data on the clinical characteristics of food-responsive PLE (FR-PLE) remain scarce. Objective To determine the clinical characteristics of FR-PLE in dogs responsive to ultralow-fat diet (ULFD) management. Animals Thirty-three dogs diagnosed with PLE based on standard diagnostic criteria. Methods Retrospective review of medical records. Clinical findings were compared between dogs with FR-PLE (FR-PLE group) and those with immunosuppressant-responsive PLE (IR-PLE) or nonresponsive PLE (NR-PLE) (IR/NR-PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR-PLE and IR/NR-PLE groups. Survival time was compared between the FR-PLE and IR/NR-PLE groups. Results Twenty-three dogs responded to ULFD management and were diagnosed with FR-PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR-PLE group than in the IR/NR-PLE group (P < .001). The AUC of CCECAI for differentiating the FR-PLE group was 0.935 (95% confidence interval [CI], 0.845-1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR-PLE group (median, not reached) than in the IR/NR-PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance Dogs that respond to ULFD management and are diagnosed with FR-PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR-PLE from IR-PLE or NR-PLE.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	0891-6640
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jvim.15720