open access

https://hdl.handle.net/2115/78724

Among the water-soluble vitamins, dietary intakes of vitamins C, B-2 and folate are associated with the reduced risk of diabetes in Japanese women but not men

英語

Japanese

2019-06-28

Cambridge University Press

British journal of nutrition

121(12)

1357-1364

Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B-2 and homocysteine-lowering effects of vitamins B-6, folate and B-12 may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40-79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B-2 and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B-1, B-3, B-5, B-6 and B-12 were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0.61(95 % CI 0.44, 0.94; P-trend = 0.04) for vitamin C, 0.56 (95 % CI 0.34, 0.93; P-trend = 0.03) for vitamin B-2 and 0.70 (95 % CI 0.46, 0.98; P-trend = 0.03) for folate. Other than that for sex (P < 0.05), the P-interactions with age, BMI, smoking status or having a family history of diabetes were >0.10. In conclusion, higher dietary intakes of vitamins C, B-2 and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.

学術雑誌論文

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© The Authors 2019

0007-1145