Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation

Shingu, Yasushige; Takada, Shingo; Yokota, Takashi; Shirakawa, Ryosuke; Yamada, Akira; Ooka, Tomonori; Katoh, Hiroki; Kubota, Suguru; Matsui, Yoshiro

Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation

Shingu, Yasushige; Takada, Shingo; Yokota, Takashi et al.

PLoS ONE, 2020, 15(4), e0224713

Permalink : https://hdl.handle.net/2115/78755

このアイテムのアクセス数:633件（2026-08-11 04:57 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/78755
タイトル	Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation
著者	Shingu, Yasushige ; Takada, Shingo ; Yokota, Takashi ; Shirakawa, Ryosuke ; Yamada, Akira ; Ooka, Tomonori ; Katoh, Hiroki ; Kubota, Suguru ; Matsui, Yoshiro
e-Rad_Researcher 30617064 著者名 Shingu, Yasushige
e-Rad_Researcher 60722329 著者名 Takada, Shingo
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
著者名 Shirakawa, Ryosuke
著者名 Yamada, Akira
e-Rad_Researcher 60507573 著者名 Ooka, Tomonori
著者名 Katoh, Hiroki
e-Rad_Researcher 70455640 著者名 Kubota, Suguru
e-Rad_Researcher 90219379 著者名 Matsui, Yoshiro
言語	英語
発行日	2020-04-21
出版者	PLOS
収録物名	PLoS ONE
巻(号)	15(4)
ページ	e0224713
抄録	Atrial metabolic disturbance contributes to the onset and development of atrial fibrillation (AF). Autophagy plays a role in maintaining the cellular energy balance. We examined whether atrial gene expressions related to fatty acid metabolism and autophagy are altered in chronic AF and whether they are related to each other. Right atrial tissue was obtained during heart surgery from 51 patients with sinus rhythm (SR, n = 38) or chronic AF (n = 13). Preoperative fasting serum free-fatty-acid levels were significantly higher in the AF patients. The atrial gene expression of fatty acid binding protein 3 (FABP3), which is involved in the cells' fatty acid uptake and intracellular fatty acid transport, was significantly increased in AF patients compared to SR patients; in the SR patients it was positively correlated with the right atrial diameter and intra-atrial electromechanical delay (EMD), parameters of structural and electrical atrial remodeling that were evaluated by an echocardiography. In contrast, the two groups' atrial contents of diacylglycerol (DAG), a toxic fatty acid metabolite, were comparable. Importantly, the atrial gene expression of microtubule-associated protein light chain 3 (LC3) was significantly increased in AF patients, and autophagy-related genes including LC3 were positively correlated with the atrial expression of FABP3. In conclusion, in chronic AF patients, the atrial expression of FABP3 was upregulated in association with autophagy-related genes without altered atrial DAG content. Our findings may support the hypothesis that dysregulated cardiac fatty acid metabolism contributes to the progression of AF and induction of autophagy has a cardioprotective effect against cardiac lipotoxicity in chronic AF.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0224713