Relationship between diabetic macular edema and choroidal layer thickness

Endo, Hiroaki; Kase, Satoru; Takahashi, Mitsuo; Saito, Michiyuki; Yokoi, Masahiko; Sugawara, Chisato; Katsuta, Satoshi; Ishida, Susumu; Kase, Manabu

Relationship between diabetic macular edema and choroidal layer thickness

Endo, Hiroaki; Kase, Satoru; Takahashi, Mitsuo et al.

PLoS ONE, 2020, 15(1), e0226630

Permalink : https://hdl.handle.net/2115/78762

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アクセス権	open access
URI	https://hdl.handle.net/2115/78762
タイトル	Relationship between diabetic macular edema and choroidal layer thickness
著者	Endo, Hiroaki ; Kase, Satoru ; Takahashi, Mitsuo ; Saito, Michiyuki ; Yokoi, Masahiko ; Sugawara, Chisato ; Katsuta, Satoshi ; Ishida, Susumu ; Kase, Manabu
著者名 Endo, Hiroaki
e-Rad_Researcher 60374394 著者名 Kase, Satoru
著者名 Takahashi, Mitsuo
e-Rad_Researcher 90443944 著者名 Saito, Michiyuki
e-Rad_Researcher 20291677 著者名 Yokoi, Masahiko
著者名 Sugawara, Chisato
著者名 Katsuta, Satoshi
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
著者名 Kase, Manabu
言語	英語
発行日	2020-01-07
出版者	PLOS
収録物名	PLoS ONE
巻(号)	15(1)
ページ	e0226630
抄録	Purpose To investigate the relationship between diabetic macular edema (DME) and the choroidal layer thickness in diabetic patients. Methods This is a retrospective observation study. Three hundred eighteen eyes of 159 diabetes mellitus (DM) patients and age-matched 100 eyes of 79 healthy controls were enrolled. DME was defined as over 300 mu m in the central retinal subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector. The central choroidal thickness (CCT), as well as inner and outer layers were determined based on enhanced depth imaging (EDI)-OCT. Diabetic patients with/without systemic diabetic treatments (DT) at the start of this study was defined as DT+ and DT-, respectively. The number of eyes examined was 62 and 256 eyes in DME+and DME-groups, respectively. DM patients were further subdivided into 4 groups with/without DME and DT; DME+DT+(35 eyes), DME-DT+(159 eyes), DME+DT-(27 eyes), and DME-DT-group (97 eyes). Multiple comparisons on CCT layers including control and each DM group were statistically examined. Results The total CCT layer was 254 +/- 83, 283 +/- 88, and 251 +/- 70 mu m in the control, DME+, and DME-group, respectively. A total CCT layer in DME+was significantly thicker than the DME-group (P < 0.05). The outer CCT layer was 195 +/- 75, 222 +/- 83, and 193 +/- 63 mu m in the control, DME+, and DME-group, respectively. The outer CCT layer in DME+ was significantly thicker than the DME-group (P < 0.05). In the subdivided groups, the total CCT layers in the control, DME+DT+, DME-DT+, DME+DT-and DME-DT-groups were 254 +/- 83, 274 +/- 88, 247 +/- 66, 290 +/- 84 and 258 +/- 75 mu m, respectively. The outer CCT layers in each group were 195 +/- 75, 214 +/- 83, 189 +/- 58, 228 +/- 77, and 201 +/- 70 mu m, respectively. Total CCT and the outer layer in DME+DT-was significantly thicker than the DME-DT+group (each P < 0.05). In contrast, there was no significant difference in inner layer between the groups. Conclusions The total and outer CCT layers of diabetic eyes were significantly thickened in the DME +DT-as compared with the DME-DT+group, suggesting that CCT may be related to the pathology of DME.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0226630