Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring

Yamasaki, Shojiro; Tomihara, Tomomi; Kimura, Goh; Ueno, Yukako; Ketema, Rahel Mesfin; Sato, Shin; Mukai, Yuuka; Sikder, Tajuddin; Kurasaki, Masaaki; Hosokawa, Toshiyuki; Saito, Takeshi

Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring

Yamasaki, Shojiro; Tomihara, Tomomi; Kimura, Goh et al.

International journal of food sciences and nutrition, 2019, 71(2), 226-234

Permalink : https://hdl.handle.net/2115/78864

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アクセス権	open access
URI	https://hdl.handle.net/2115/78864
タイトル	Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring
著者	Yamasaki, Shojiro ; Tomihara, Tomomi ; Kimura, Goh ; Ueno, Yukako ; Ketema, Rahel Mesfin ; Sato, Shin ; Mukai, Yuuka ; Sikder, Tajuddin ; Kurasaki, Masaaki ; Hosokawa, Toshiyuki ; Saito, Takeshi
著者名 Yamasaki, Shojiro
著者名 Tomihara, Tomomi
著者名 Kimura, Goh
著者名 Ueno, Yukako
著者名 Ketema, Rahel Mesfin
e-Rad_Researcher 40310099 著者名 Sato, Shin
e-Rad_Researcher 60331211 著者名 Mukai, Yuuka
著者名 Sikder, Tajuddin
e-Rad_Researcher 80161727 著者名 Kurasaki, Masaaki
e-Rad_Researcher 00157025 著者名 Hosokawa, Toshiyuki
e-Rad_Researcher 40153811 著者名 Saito, Takeshi
言語	英語
キーワード	Resveratrol
	maternal
	adult offspring
	cholesterol
発行日	2019-07-10
出版者	Taylor & Francis
収録物名	International journal of food sciences and nutrition
巻(号)	71(2)
ページ	226-234
抄録	Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the Author’s Original Manuscript of an article published by Taylor & Francis in International journal of food sciences and nutrition on 10 Jul 2019, available online: http://www.tandfonline.com/10.1080/09637486.2019.1639638.
PISSN	0963-7486
EISSN	1465-3478
関連情報	PMID 31290360
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/09637486.2019.1639638