Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA

Mikawa, Yohei; Alam, Mohammad Towfik; Hossain, Elora; Yanagawa-Matsuda, Aya; Kitamura, Tetsuya; Yasuda, Motoaki; Habiba, Umma; Ahmed, Ishraque; Kitagawa, Yoshimasa; Shindoh, Masanobu; Higashino, Fumihiro

Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA

Mikawa, Yohei; Alam, Mohammad Towfik; Hossain, Elora et al.

Cancers, 2020, 12(5), 1205

Permalink : https://hdl.handle.net/2115/78873

このアイテムのアクセス数:669件（2026-08-18 18:14 集計）

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https://doi.org/10.3390/cancers12051205			25

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/78873
タイトル	Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA
著者	Mikawa, Yohei ; Alam, Mohammad Towfik ; Hossain, Elora ; Yanagawa-Matsuda, Aya ; Kitamura, Tetsuya ; Yasuda, Motoaki ; Habiba, Umma ; Ahmed, Ishraque ; Kitagawa, Yoshimasa ; Shindoh, Masanobu ; Higashino, Fumihiro
著者名 Mikawa, Yohei
e-Rad_Researcher 60641694 著者名 Alam, Mohammad Towfik
著者名 Hossain, Elora
e-Rad_Researcher 60514312 著者名 Yanagawa-Matsuda, Aya
e-Rad_Researcher 00451451 著者名 Kitamura, Tetsuya
e-Rad_Researcher 90239765 著者名 Yasuda, Motoaki
e-Rad_Researcher 40755914 著者名 Habiba, Umma
著者名 Ahmed, Ishraque
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
著者名 Shindoh, Masanobu
e-Rad_Researcher 50301891 著者名 Higashino, Fumihiro
言語	英語
キーワード	Oncolytic adenovirus
	E1A
	AU-rich element (ARE)
	HuR
	ARE-mRNA
	E1B55k
	Hexon
	TNF-alpha
	c-fos
	LPS
発行日	2020-05
出版者	MDPI
収録物名	Cancers
巻(号)	12(5)
ページ	1205
抄録	AU-rich elements (AREs) are RNA elements that enhance the rapid decay of mRNAs, including those of genes required for cell growth and proliferation. HuR, a member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins, is involved in the stabilization of ARE-mRNA. The level of HuR in the cytoplasm is up-regulated in most cancer cells, resulting in the stabilization of ARE-mRNA. We developed the adenoviruses AdARET and AdAREF, which include the ARE of TNF-alpha and c-fos genes in the 3 ' -untranslated regions of the E1A gene, respectively. The expression of the E1A protein was higher in cancer cells than in normal cells, and virus production and cytolytic activities were also higher in many types of cancer cells. The inhibition of ARE-mRNA stabilization resulted in a reduction in viral replication, demonstrating that the stabilization system was required for production of the virus. The growth of human tumors that formed in nude mice was inhibited by an intratumoral injection of AdARET and AdAREF. These results indicate that these viruses have potential as oncolytic adenoviruses in the vast majority of cancers in which ARE-mRNA is stabilized.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/cancers12051205