Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-G(q/11) protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells

Horinouchi, Takahiro; Mazaki, Yuichi; Terada, Koji; Miwa, Soichi

Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-G(q/11) protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells

Horinouchi, Takahiro; Mazaki, Yuichi; Terada, Koji et al.

Journal of pharmacological sciences, 2020, 143(4), 315-319

Permalink : https://hdl.handle.net/2115/78969

このアイテムのアクセス数:510件（2026-08-12 01:58 集計）

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https://doi.org/10.1016/j.jphs.2019.06.009			12

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/78969
タイトル	Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-G(q/11) protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells
著者	Horinouchi, Takahiro ; Mazaki, Yuichi ; Terada, Koji ; Miwa, Soichi
e-Rad_Researcher 20307771 著者名 Horinouchi, Takahiro
著者名 Mazaki, Yuichi
e-Rad_Researcher 70342722 著者名 Terada, Koji
e-Rad_Researcher 40157706 著者名 Miwa, Soichi
言語	英語
キーワード	Ca2+-sensing receptor
	Endothelial nitric oxide synthase
	Extracellular Ca2+
発行日	2020-08
出版者	Japanese Pharmacological Society
収録物名	Journal of pharmacological sciences
巻(号)	143(4)
ページ	315-319
抄録	This study examined the possible involvement of Ca2+-sensing receptor (CaSR) in nitric oxide (NO) production in human vascular endothelial cells. Extracellular Ca2+ elevated the intracellular Ca2+ concentration, the endothelial NO synthase (eNOS) phosphorylation level, and NO release from the cells. These responses were inhibited by a CaSR antagonist and a G(q/11) protein inhibitor. Application of an endothelial cell suspension induced vasorelaxation in isolated rat thoracic aorta precontracted by phenylephrine. Adding an NO scavenger to the organ bath abolished this vasorelaxation response. These results suggest that extracellular Ca2+ promotes NO generation via CaSR- and G(q/11) protein-mediated eNOS activation. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1347-8613
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.jphs.2019.06.009