Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories

Nomura, Hiroshi; Mizuta, Hiroto; Norimoto, Hiroaki et al.

Biological psychiatry, 2019, 86(3), 230-239

Permalink : https://hdl.handle.net/2115/79001

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アクセス権
open access
URI
https://hdl.handle.net/2115/79001
タイトル
Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories
著者
Nomura, Hiroshi ; Mizuta, Hiroto ; Norimoto, Hiroaki ; Masuda, Fumitaka ; Miura, Yuki ; Kubo, Ayame ; Kojima, Hiroto ; Ashizuka, Aoi ; Matsukawa, Noriko ; Baraki, Zohal ; Hitora-Imamura, Natsuko ; Nakayama, Daisuke ; Ishikawa, Tomoe ; Okada, Mami ; Orita, Ken ; Saito, Ryoki ; Yamauchi, Naoki ; Sano, Yamato ; Kusuhara, Hiroyuki ; Minami, Masabumi ; Takahashi, Hidehiko ; Ikegaya, Yuji
e-Rad_Researcher
10549603
著者名
Nomura, Hiroshi
著者名
Mizuta, Hiroto
著者名
Norimoto, Hiroaki
著者名
Masuda, Fumitaka
著者名
Miura, Yuki
著者名
Kubo, Ayame
著者名
Kojima, Hiroto
著者名
Ashizuka, Aoi
著者名
Matsukawa, Noriko
著者名
Baraki, Zohal
著者名
Hitora-Imamura, Natsuko
著者名
Nakayama, Daisuke
著者名
Ishikawa, Tomoe
著者名
Okada, Mami
著者名
Orita, Ken
著者名
Saito, Ryoki
著者名
Yamauchi, Naoki
著者名
Sano, Yamato
著者名
Kusuhara, Hiroyuki
e-Rad_Researcher
20243040
著者名
Minami, Masabumi
著者名
Takahashi, Hidehiko
著者名
Ikegaya, Yuji
言語
英語
キーワード
Histamine H-3 receptor
Memory recovery
Object recognition memory
Perirhinal cortex
Retrieval
Stochastic resonance
発行日
2019-08-01
出版者
Elsevier
収録物名
Biological psychiatry
巻(号)
86(3)
ページ
230-239
抄録
BACKGROUND: A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H-3 receptor inverse agonists upregulate histamine release, the inverse agonists may enhance learning and memory. However, whether the inverse agonists promote the retrieval of forgotten long-term memory has not yet been determined. METHODS: Here, we employed multidisciplinary methods, including mouse behavior, calcium imaging, and chemogenetic manipulation, to examine whether and how the histamine H-3 receptor inverse agonists, thioperamide and betahistine, promote the retrieval of a forgotten long-term object memory in mice. In addition, we conducted a randomized double-blind, placebo-controlled crossover trial in healthy adult participants to investigate whether betahistine treatment promotes memory retrieval in humans. RESULTS: The treatment of H-3 receptor inverse agonists induced the recall of forgotten memories even 1 week and 1 month after training in mice. The memory recovery was mediated by the disinhibition of histamine release in the perirhinal cortex, which activated the histamine H-2 receptor. Histamine depolarized perirhinal cortex neurons, enhanced their spontaneous activity, and facilitated the reactivation of behaviorally activated neuronal ensembles. A human clinical trial revealed that treatment of H-3 receptor inverse agonists is specifically more effective for items that are more difficult to remember and subjects with poorer performance. CONCLUSIONS: These results highlight a novel interaction between the central histamine signaling and memory engrains.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0006-3223
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.biopsych.2018.11.009