Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood : The Hokkaido study

Miyashita, Chihiro; Araki, Atsuko; Mitsui, Takahiko et al.

Environment international, 2018, 117, 175-185

Permalink : https://hdl.handle.net/2115/79016

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/79016
タイトル
Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood : The Hokkaido study
その他のタイトル
Maternal dioxins and cord blood hormones
著者
Miyashita, Chihiro ; Araki, Atsuko ; Mitsui, Takahiko ; Itoh, Sachiko ; Goudarzi, Houman ; Sasaki, Seiko ; Kajiwara, Jumboku ; Hori, Tsuguhide ; Cho, Kazutoshi ; Moriya, Kimihiko ; Shinohara, Nobuo ; Nonomura, Katsuya ; Kishi, Reiko
e-Rad_Researcher
70632389
著者名
Miyashita, Chihiro
e-Rad_Researcher
00619885
著者名
Araki, Atsuko
e-Rad_Researcher
90421966
著者名
Mitsui, Takahiko
e-Rad_Researcher
90580936
著者名
Itoh, Sachiko
e-Rad_Researcher
40713607
著者名
Goudarzi, Houman
e-Rad_Researcher
30448831
著者名
Sasaki, Seiko
著者名
Kajiwara, Jumboku
著者名
Hori, Tsuguhide
e-Rad_Researcher
10312365
著者名
Cho, Kazutoshi
e-Rad_Researcher
20374233
著者名
Moriya, Kimihiko
e-Rad_Researcher
90250422
著者名
Shinohara, Nobuo
e-Rad_Researcher
60113750
著者名
Nonomura, Katsuya
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
言語
英語
キーワード
Dioxin-like compounds
Reproductive hormones
Cord blood
Prenatal exposure
発行日
2018-08
出版者
Elsevier
収録物名
Environment international
巻(号)
117
ページ
175-185
抄録
Background: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. Objective: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. Methods: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples. Results: Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples. Conclusions: Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0160-4120
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.envint.2018.04.046