Effect of microtubule immobilization by glutaraldehyde on kinesin-driven cargo transport

Nasrin, Syeda Rubaiya; Kabir, Arif Md. Rashedul; Sada, Kazuki et al.

Polymer journal, 2020, 52, 655-660

Permalink : https://hdl.handle.net/2115/79024

このアイテムのアクセス数:629件（2026-08-16 09:39 集計）

ファイル	フォーマット	サイズ	閲覧回数	説明
Polymer journal_20200204	pdf	92.5 KB	639
Polymer journal_20200204_Figures	pdf	310 KB	286

アクセス権	open access
URI	https://hdl.handle.net/2115/79024
タイトル	Effect of microtubule immobilization by glutaraldehyde on kinesin-driven cargo transport
著者	Nasrin, Syeda Rubaiya ; Kabir, Arif Md. Rashedul ; Sada, Kazuki ; Kakugo, Akira
著者名 Nasrin, Syeda Rubaiya
著者名 Kabir, Arif Md. Rashedul
著者名 Sada, Kazuki
e-Rad_Researcher 10374224 著者名 Kakugo, Akira
言語	英語
発行日	2020-02-04
出版者	Nature Publishing Group
収録物名	Polymer journal
巻(号)	52
ページ	655-660
抄録	The glutaraldehyde fixation method for fixing tissues is attractive for its ease of use and straightforward surface chemistry. We investigated the effect of glutaraldehyde-induced microtubule immobilization on kinesin-driven cargo transport along microtubules and found that at low glutaraldehyde concentrations, the microtubule-kinesin interaction remains unperturbed. Such findings may facilitate the application of the glutaraldehyde fixation method for many in vitro studies aiming to build nanodevices powered by the microtubule-motor protein interaction.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0032-3896
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/s41428-020-0309-x