Serological evidence of Zika virus infection in non-human primates in Zambia

Wastika, Christida E.; Sasaki, Michihito; Yoshii, Kentaro; Anindita, Paulina D.; Hang'ombe, Bernard M.; Mweene, Aaron S.; Kobayashi, Shintaro; Kariwa, Hiroaki; Carr, Michael J.; Hall, William W.; Eshita, Yuki; Orba, Yasuko; Sawa, Hirofumi

Serological evidence of Zika virus infection in non-human primates in Zambia

Wastika, Christida E.; Sasaki, Michihito; Yoshii, Kentaro et al.

Archives of virology, 2019, 164(8), 2165-2170

Permalink : https://hdl.handle.net/2115/79038

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アクセス権	open access
URI	https://hdl.handle.net/2115/79038
タイトル	Serological evidence of Zika virus infection in non-human primates in Zambia
著者	Wastika, Christida E. ; Sasaki, Michihito ; Yoshii, Kentaro ; Anindita, Paulina D. ; Hang'ombe, Bernard M. ; Mweene, Aaron S. ; Kobayashi, Shintaro ; Kariwa, Hiroaki ; Carr, Michael J. ; Hall, William W. ; Eshita, Yuki ; Orba, Yasuko ; Sawa, Hirofumi
著者名 Wastika, Christida E.
著者名 Sasaki, Michihito
著者名 Yoshii, Kentaro
著者名 Anindita, Paulina D.
著者名 Hang'ombe, Bernard M.
著者名 Mweene, Aaron S.
著者名 Kobayashi, Shintaro
著者名 Kariwa, Hiroaki
著者名 Carr, Michael J.
著者名 Hall, William W.
著者名 Eshita, Yuki
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
言語	英語
キーワード	Zika virus
発行日	2019-08
出版者	Springer
収録物名	Archives of virology
巻(号)	164(8)
ページ	2165-2170
抄録	Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0304-8608
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00705-019-04302-0