Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors

Chiba, Hiroki; Kitta, Takeya; Ohmura, Yu; Higuchi, Madoka; Kon, Masafumi; Nakamura, Michiko; Yoshioka, Mitsuhiro; Shinohara, Nobuo

Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors

Chiba, Hiroki; Kitta, Takeya; Ohmura, Yu et al.

International journal of urology, 2020, 27(8), 684-689

Permalink : https://hdl.handle.net/2115/79042

このアイテムのアクセス数:618件（2026-08-26 00:15 集計）

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https://doi.org/10.1111/iju.14267			34

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/79042
タイトル	Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors
著者	Chiba, Hiroki ; Kitta, Takeya ; Ohmura, Yu ; Higuchi, Madoka ; Kon, Masafumi ; Nakamura, Michiko ; Yoshioka, Mitsuhiro ; Shinohara, Nobuo
著者名 Chiba, Hiroki
e-Rad_Researcher 40374441 著者名 Kitta, Takeya
e-Rad_Researcher 80597659 著者名 Ohmura, Yu
著者名 Higuchi, Madoka
e-Rad_Researcher 40802799 著者名 Kon, Masafumi
e-Rad_Researcher 60571718 著者名 Nakamura, Michiko
e-Rad_Researcher 40182729 著者名 Yoshioka, Mitsuhiro
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
言語	英語
キーワード	central nervous system
	microinjection
	micturition reflex
	prefrontal cortex
	serotonin
発行日	2020-08
出版者	John Wiley & Sons
収録物名	International journal of urology
巻(号)	27(8)
ページ	684-689
抄録	Objectives To identify the types of serotonin (5-hydroxytryptamine) receptors of the prefrontal cortex related to the micturition reflex. Methods Female Sprague-Dawley rats and a microinjection method were used for this study. Stainless steel guide cannulas were implanted bilaterally into the prefrontal cortex, and a polyethylene catheter was inserted into the bladder. Cystometric parameters (intercontraction interval and maximum voiding pressure) were measured before and after injection of any one of six specific antagonists of 5-hydroxytriptamine receptors (5-hydroxytryptamine 1A, 5-hydroxytryptamine 2A, 5-hydroxytryptamine 2C, 5-hydroxytryptamine 3, 5-hydroxytryptamine 4 and 5-hydroxytryptamine 7) into the prefrontal cortex. The prefrontal cortex was divided into two regions, namely the prelimbic cortex and the infralimbic cortex. The experiments were carried out in conscious and free-moving rats. Results The intercontraction interval value increased significantly after injection of the 5-hydroxytriptamine 2A receptor antagonist, MDL11939, into the prelimbic cortex of the rat prefrontal cortex (7.68 +/- 1.28vs9.02 +/- 1.41 min,P < 0.05), whereas the intercontraction interval value decreased significantly after injection of the 5-hydroxytriptamine 7 antagonist SB269970 into the prelimbic cortex (9.42 +/- 0.39vs8.14 +/- 0.71 min,P < 0.05). The intercontraction interval was unaffected by injection of either of these two antagonists into the infralimbic cortex. The other four antagonists (5-hydroxytryptamine 1A, 5-hydroxytryptamine 2C, 5-hydroxytryptamine 3 and 5-hydroxytryptamine 4) had no effect on the intercontraction interval after injection into the prelimbic cortex and the infralimbic cortex. The maximum voiding pressure was unaffected by injection of any one of the six 5-hydroxytriptamine antagonists into the prelimbic cortex and infralimbic cortex. Conclusions In the rat prefrontal cortex5-hydroxytryptamine 2A receptors excite the micturition reflex, whereas 5-hydroxytryptamine 7 receptors inhibit this reflex.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0919-8172
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/iju.14267