Investigation of energy absorption by clustered gold nanoparticles

Kwon, Jihun; Sutherland, Kenneth; Makarova, Anastasia; Matsuura, Taeko; Hashimoto, Takayuki; Peng, Hao; Toshito, Toshiyuki; Umegaki, Kikuo; Shirato, Hiroki; Shimizu, Shinichi

Investigation of energy absorption by clustered gold nanoparticles

Kwon, Jihun; Sutherland, Kenneth; Makarova, Anastasia et al.

Nuclear instruments & methods in physics research section b-beam interactions with materials and atoms, 2018, 429, 34-41

Permalink : https://hdl.handle.net/2115/79061

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アクセス権	open access
URI	https://hdl.handle.net/2115/79061
タイトル	Investigation of energy absorption by clustered gold nanoparticles
著者	Kwon, Jihun ; Sutherland, Kenneth ; Makarova, Anastasia ; Matsuura, Taeko ; Hashimoto, Takayuki ; Peng, Hao ; Toshito, Toshiyuki ; Umegaki, Kikuo ; Shirato, Hiroki ; Shimizu, Shinichi
著者名 Kwon, Jihun
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth
著者名 Makarova, Anastasia
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
e-Rad_Researcher 60400678 著者名 Hashimoto, Takayuki
著者名 Peng, Hao
著者名 Toshito, Toshiyuki
e-Rad_Researcher 40643193 著者名 Umegaki, Kikuo
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
言語	英語
キーワード	Gold nanoparticles
	Clustering
	Dose enhancement
	Radiation sensitizer
	Monte Carlo simulation
発行日	2018-08-15
出版者	Elsevier
収録物名	Nuclear instruments & methods in physics research section b-beam interactions with materials and atoms
巻(号)	429
ページ	34-41
抄録	The utilization of gold nanoparticles (GNPs) as a radiation sensitizer has received broad attention. Although GNPs form clusters in living cells, most previous simulation studies have assumed a homogeneous distribution of GNPs. In this study, a GNP cluster was constructed for simulations and the impact of cluster formation on dose enhancement was examined. Energy absorption by the GNPs was compared between clustered and homogeneous distributions for several different GNP concentrations and diameters under 100 keV X-ray irradiations. Our simulations showed that clusters more efficiently absorbed the secondary electrons and photons produced by GNPs themselves. Furthermore, the impact of cluster formation on dose enhancement was more significant for smaller GNPs and higher concentrations. Our results suggest that previous simulations assuming a homogeneous GNP distribution have overestimated the dose enhancement, especially for smaller GNPs and higher concentrations. These findings should guide the selection of GNP size and concentration for effectively optimizing dose enhancement in future studies.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0168-583X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.nimb.2018.05.033