Therapeutic effects and adaptive limits of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models

Onodera, Tomohiro; Baba, Rikiya; Kasahara, Yasuhiko; Tsuda, Toshihiko; Iwasaki, Norimasa

Therapeutic effects and adaptive limits of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models

Onodera, Tomohiro; Baba, Rikiya; Kasahara, Yasuhiko et al.

Regenerative Therapy, 2020, 14, 154-159

Permalink : https://hdl.handle.net/2115/79073

このアイテムのアクセス数:560件（2026-08-09 10:51 集計）

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https://doi.org/10.1016/j.reth.2020.01.001			14

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アクセス権	open access
URI	https://hdl.handle.net/2115/79073
タイトル	Therapeutic effects and adaptive limits of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models
著者	Onodera, Tomohiro ; Baba, Rikiya ; Kasahara, Yasuhiko ; Tsuda, Toshihiko ; Iwasaki, Norimasa
e-Rad_Researcher 70547174 著者名 Onodera, Tomohiro
e-Rad_Researcher 40815742 著者名 Baba, Rikiya
e-Rad_Researcher 00581927 著者名 Kasahara, Yasuhiko
著者名 Tsuda, Toshihiko
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
キーワード	Cartilage
	Alginate
	Acellular technique
	Animal model
発行日	2020-06
出版者	Elsevier
収録物名	Regenerative Therapy
巻(号)	14
ページ	154-159
抄録	Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5.0 mm) were created on each patellar groove in both knees of 10 dogs. Defects were divided into four groups (n 1 / 4 10 each): Group 1, untreated 3.0-mm defect; Group 2, 3.0-mm defect with UPAL gel; Group 3, untreated 5.0-mm defect; and Group 4, 5.0-mm defect with UPAL gel. All surgical procedures were performed by individuals unfamiliar with the technique at an independent institution. Articular surfaces were evaluated grossly and histologically at 27 weeks after operation. Results: UPAL gel-treated osteochondral defects showed signi ficantly improved gross appearance in Group 4 and histological appearance in Groups 2 and 4. Reparative tissues in the 3.0-mm defect with UPAL gel were replaced by hyaline-like cartilage tissue. The 5.0-mm defects with UPAL gel were mostly covered with fibrocartilaginous tissue, whereas UPAL gel-untreated defects mostly remained uncovered by any tissue. Conclusions: Although an acellular technique using UPAL gel implantation signi ficantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans. (C) 2020, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2352-3204
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.reth.2020.01.001