Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure

Aly, Mahmoud Khamis; Ninomiya, Kensuke; Adachi, Shungo; Natsume, Tohru; Hirose, Tetsuro

Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure

Aly, Mahmoud Khamis; Ninomiya, Kensuke; Adachi, Shungo et al.

Biochemical and biophysical research communications, 2019, 516(2), 419-423

Permalink : https://hdl.handle.net/2115/79081

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アクセス権	open access
URI	https://hdl.handle.net/2115/79081
タイトル	Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure
著者	Aly, Mahmoud Khamis ; Ninomiya, Kensuke ; Adachi, Shungo ; Natsume, Tohru ; Hirose, Tetsuro
著者名 Aly, Mahmoud Khamis
e-Rad_Researcher 00437279 著者名 Ninomiya, Kensuke
著者名 Adachi, Shungo
著者名 Natsume, Tohru
e-Rad_Researcher 30273220 著者名 Hirose, Tetsuro
言語	英語
キーワード	Nuclear stress bodies
	Long noncoding RNA
	HSATIII
	RNA-binding protein
	Primate-specific genes
	Thermal stress
発行日	2019-08-20
出版者	Elsevier
収録物名	Biochemical and biophysical research communications
巻(号)	516(2)
ページ	419-423
抄録	Nuclear stress bodies (nSBs) are thermal stress-inducible membrane-less nuclear bodies that are formed on highly repetitive satellite Ill architectural noncoding RNAs (HSATIII arcRNAs). Upon thermal stress exposure, HSATIII expression is induced to sequestrate specific sets of RNA-binding proteins and form nSBs. The major population of nSBs contain SAFB as a marker, whereas the minor population are SAFB-negative. Here, we found that HNRNPM, which was previously reported to localize in nuclear foci adjacent to SAFB-positive foci upon thermal stress, localizes in a minor population of HSATIII-dependent nSBs. Hence, we used the terms nSB-S and nSB-M to distinguish the SAFB foci and HNRNPM foci, respectively. Analysis of the components of the nSBs revealed that each set contains distinct RNA-binding proteins, including SLTM and NCO5A in nSB-Ss and HNRNPA1 and HNRNPH1 in nSB-Ms. Overall, our findings indicate that two sets of nSBs containing HSATIII arcRNAs and distinct sets of RNA-binding proteins are formed upon thermal stress exposure.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
関連情報	PMID 31227213
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2019.06.061