Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer

Kato, Fumi; Kudo, Kohsuke; Yamashita, Hiroko; Baba, Motoi; Shimizu, Ai; Oyama-Manabe, Noriko; Kinoshita, Rumiko; Li, Ruijiang; Shirato, Hiroki

Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer

Kato, Fumi; Kudo, Kohsuke; Yamashita, Hiroko et al.

Breast cancer, 2019, 26(5), 628-636

Permalink : https://hdl.handle.net/2115/79147

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アクセス権	open access
URI	https://hdl.handle.net/2115/79147
タイトル	Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer
著者	Kato, Fumi ; Kudo, Kohsuke ; Yamashita, Hiroko ; Baba, Motoi ; Shimizu, Ai ; Oyama-Manabe, Noriko ; Kinoshita, Rumiko ; Li, Ruijiang ; Shirato, Hiroki
e-Rad_Researcher 80399865 著者名 Kato, Fumi
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 70332947 著者名 Yamashita, Hiroko
著者名 Baba, Motoi
著者名 Shimizu, Ai
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 70507582 著者名 Kinoshita, Rumiko
著者名 Li, Ruijiang
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Breast cancer
	Axillary lymph node metastasis
	Magnetic resonance imaging
	Diffusion-weighed imaging
発行日	2019-09
出版者	Springer
収録物名	Breast cancer
巻(号)	26(5)
ページ	628-636
抄録	Background We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal A-like breast cancers with clinically negative nodes in comparison with the mean ADC. Methods Forty-four luminal A-like breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN positive (n = 12) and LN negative (n = 32) groups. An ROC curve was drawn to determine the best cutoff value to differentiate LN status. Correlations between mean and minimum ADC values and the number of metastatic axillary LNs were investigated. Results Mean and minimum ADC values of breast lesions with positive LN were significantly lower than those with negative LN (mean 839.9 +/- 110.9 vs. 1022.2 +/- 250.0 x 10(- 6) mm(2)/s, p = 0.027, minimum 696.7 +/- 128.0 vs. 925.0 +/- 257.6 x 10(- 6) mm(2)/s, p = 0.004). The sensitivity and NPV using the best cutoff value from ROC using both mean and minimum ADC were 100%. AUC of the minimum ADC (0.784) was higher than that of the mean ADC (0.719). Statistically significant negative correlations were observed between both mean and minimum ADCs and number of positive LNs, with stronger correlation to minimum ADC than mean ADC. Conclusions The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal A-like breast cancer with clinically negative nodes, with high sensitivity and high NPV.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Breast cancer. The final authenticated version is available online at: https://doi.org/10.1007/s12282-019-00969-0
PISSN	1340-6868
関連情報	PMID 30937834
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12282-019-00969-0