Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study

Fujimori, Motoshi; Kamishima, Tamotsu; Narita, Akihiro; Henmi, Mihoko; Kato, Masaru; Sutherland, Kenneth; Nishida, Mutsumi; Tanaka, Yuki; Yutong, Lu; Tanimura, Kazuhide; Atsumi, Tatsuya

Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study

Fujimori, Motoshi; Kamishima, Tamotsu; Narita, Akihiro et al.

Rheumatology international, 2019, 39(8), 1413-1421

Permalink : https://hdl.handle.net/2115/79158

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アクセス権	open access
URI	https://hdl.handle.net/2115/79158
タイトル	Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study
著者	Fujimori, Motoshi ; Kamishima, Tamotsu ; Narita, Akihiro ; Henmi, Mihoko ; Kato, Masaru ; Sutherland, Kenneth ; Nishida, Mutsumi ; Tanaka, Yuki ; Yutong, Lu ; Tanimura, Kazuhide ; Atsumi, Tatsuya
著者名 Fujimori, Motoshi
e-Rad_Researcher 10399868 著者名 Kamishima, Tamotsu
著者名 Narita, Akihiro
著者名 Henmi, Mihoko
e-Rad_Researcher 10755896 著者名 Kato, Masaru
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth
e-Rad_Researcher 90404722 著者名 Nishida, Mutsumi
e-Rad_Researcher 50794020 著者名 Tanaka, Yuki
著者名 Yutong, Lu
著者名 Tanimura, Kazuhide
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Arthritis
	Ultrasonography
	Hand
	Bone
	Synovitis
	Radiography
発行日	2019-08
出版者	Springer
収録物名	Rheumatology international
巻(号)	39(8)
ページ	1413-1421
抄録	Ultrasonography is useful for assessment of synovitis in the hand of rheumatoid arthritis (RA) patients. The aim of this study was to investigate the predictive value of the quantitative power Doppler (PD) signal assessment in the subchondral bone region of the metacarpophalangeal (MCP) joint in patients with RA showing radiographic progression of the hand by comparing with those of previously reported scoring systems. Twenty-two patients (20 women) with RA who underwent power Doppler ultrasonography (PDUS) of the bilateral one to five MCP joints at baseline were included in the study. Radiography of both hands was performed at baseline and at 1year. PDUS of the synovial space was evaluated according to semi-quantitative scoring (0-3) and quantitative measurement (0-100%). The PD signal in the subchondral bone region was qualitatively (0, 1) and quantitatively (mm(2)) assessed. The performance of PDUS assessment was compared using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the risk ratio (RR). As a predictor for radiographic progression, the quantitative PD signal assessment in the subchondral bone region (AUC=0.842, p<0.01) was equivalent to quantitative vascularity (AUC=0.817, p<0.05) and semi-quantitative scoring (AUC=0.754, p<0.05). As for the RR of the PD signal in the subchondral bone region for radiographic progression, the quantitative PD signal assessment was 5.40 (p<0.01), whereas the qualitative PD signal assessment was 1.60 (p=0.204). Quantitative PD signal assessment in the subchondral bone region can predict radiographic progression in the hand of RA patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0172-8172
関連情報	PMID 31089859
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00296-019-04320-w