Oral Supplementation of the Vitamin D Metabolite 25(OH)D(3)Against Influenza Virus Infection in Mice

Hayashi, Hirotaka; Okamatsu, Masatoshi; Ogasawara, Honami; Tsugawa, Naoko; Isoda, Norikazu; Matsuno, Keita; Sakoda, Yoshihiro

Oral Supplementation of the Vitamin D Metabolite 25(OH)D(3)Against Influenza Virus Infection in Mice

Hayashi, Hirotaka; Okamatsu, Masatoshi; Ogasawara, Honami et al.

Nutrients, 2020, 12(7), 2000

Permalink : https://hdl.handle.net/2115/79175

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アクセス権	open access
URI	https://hdl.handle.net/2115/79175
タイトル	Oral Supplementation of the Vitamin D Metabolite 25(OH)D(3)Against Influenza Virus Infection in Mice
著者	Hayashi, Hirotaka ; Okamatsu, Masatoshi ; Ogasawara, Honami ; Tsugawa, Naoko ; Isoda, Norikazu ; Matsuno, Keita ; Sakoda, Yoshihiro
著者名 Hayashi, Hirotaka
著者名 Okamatsu, Masatoshi
著者名 Ogasawara, Honami
著者名 Tsugawa, Naoko
著者名 Isoda, Norikazu
著者名 Matsuno, Keita
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
言語	英語
キーワード	vitamin D
	25-hydroxyvitamin D-3
	cytokines
	influenza
発行日	2020-07
出版者	MDPI
収録物名	Nutrients
巻(号)	12(7)
ページ	2000
抄録	Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)(2)D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect. Here, to investigate whether oral supplementation of 25-hydroxyvitamin D-3[25(OH)D-3], a major form of vitamin D metabolite 25(OH)D, has a prophylactic effect on influenza A virus infection, mice were fed a diet containing a high dose of 25(OH)D(3)and were challenged with the influenza virus. In the lungs of 25(OH)D-3-fed mice, the viral titers were significantly lower than in the lungs of standardly fed mice. Additionally, the proinflammatory cytokines IL-5 and IFN-gamma were significantly downregulated after viral infection in 25(OH)D-3-fed mice, while anti-inflammatory cytokines were not significantly upregulated. These results indicate that 25(OH)D(3)suppresses the production of inflammatory cytokines and reduces virus replication and clinical manifestations of influenza virus infection in a mouse model.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/nu12072000