Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

Boonyarattanasoonthorn, Tussapon; Elewa, Yaser Hosny Ali; Tag-El-Din-Hassan, Hassan T.; Morimatsu, Masami; Agui, Takashi

Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

Boonyarattanasoonthorn, Tussapon; Elewa, Yaser Hosny Ali; Tag-El-Din-Hassan, Hassan T. et al.

Infection, Genetics and Evolution, 2019, 73, 55-65

Permalink : https://hdl.handle.net/2115/79200

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アクセス権	open access
URI	https://hdl.handle.net/2115/79200
タイトル	Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice
著者	Boonyarattanasoonthorn, Tussapon ; Elewa, Yaser Hosny Ali ; Tag-El-Din-Hassan, Hassan T. ; Morimatsu, Masami ; Agui, Takashi
著者名 Boonyarattanasoonthorn, Tussapon
著者名 Elewa, Yaser Hosny Ali
著者名 Tag-El-Din-Hassan, Hassan T.
e-Rad_Researcher 70241370 著者名 Morimatsu, Masami
e-Rad_Researcher 00212457 著者名 Agui, Takashi
言語	英語
キーワード	Mycoplasma pulmonis
	Pneumonia
	Cellular immune response
	Cytokine
	Susceptibility
	Inbred mouse
発行日	2019-09
出版者	Elsevier
収録物名	Infection, Genetics and Evolution
巻(号)	73
ページ	55-65
抄録	Mycoplasma infections cause respiratory tract damages and atypical pneumonia, resulting in serious problems in humans and animals worldwide. It is well known that laboratory inbred mouse strains show various susceptibility to Mycoplasma pulmonis (M. pulmonis) infection, which causes murine respiratory mycoplasmosis. In this study, we aimed to demonstrate the difference in cellular immune responses between resistant strain, C57BL/6NCrSlc (B6) and susceptible strain, DBA/2CrSlc (D2) after challenging M. pulmonis infection. D2 mice showed higher amount of bacterial proliferation in lung, higher pulmonary infiltration of immune cells such as neutrophils, macrophages, and lymphocytes, and higher levels of interleukin (IL)-1 beta, IL-6, IL-17A, and tumor necrosis factor-alpha in bronchoalveolar lavage fluid than did B6 mice. The results of this study suggest that D2 mice are more susceptible than B6 mice to M. pulmonis infection due to a hyper-immune inflammatory response.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
PISSN	1567-1348
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.meegid.2019.04.019