The risk factors for hepatic steatosis in patients with primary aldosteronism

Shibayama, Yui; Wada, Norio; Baba, Shuhei; Obara, Shinji; Sakai, Hidetsugu; Usubuchi, Hiroaki; Terae, Satoshi; Nakamura, Akinobu; Atsumi, Tatsuya

The risk factors for hepatic steatosis in patients with primary aldosteronism

Shibayama, Yui; Wada, Norio; Baba, Shuhei et al.

Endocrine journal, 2020, 67(6), 623-629

Permalink : https://hdl.handle.net/2115/79203

このアイテムのアクセス数:532件（2026-08-19 18:51 集計）

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https://doi.org/10.1507/endocrj.EJ19-0600			14

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/79203
タイトル	The risk factors for hepatic steatosis in patients with primary aldosteronism
著者	Shibayama, Yui ; Wada, Norio ; Baba, Shuhei ; Obara, Shinji ; Sakai, Hidetsugu ; Usubuchi, Hiroaki ; Terae, Satoshi ; Nakamura, Akinobu ; Atsumi, Tatsuya
著者名 Shibayama, Yui
著者名 Wada, Norio
著者名 Baba, Shuhei
著者名 Obara, Shinji
著者名 Sakai, Hidetsugu
著者名 Usubuchi, Hiroaki
e-Rad_Researcher 40240634 著者名 Terae, Satoshi
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Non-alcoholic fatty liver disease
	Primary aldosteronism
	Intra-abdominal fat
	Obesity
	Computed tomography
発行日	2020
出版者	社団法人日本内分泌学会 The Japan Endocrine Society
収録物名	Endocrine journal
巻(号)	67(6)
ページ	623-629
抄録	Patients with primary aldosteronism (PA) are complicated by metabolic syndrome more frequently than those without PA. Hyperaldosteronism has been reported to be associated with a higher prevalence of non-alcoholic fatty liver disease (NAFLD). We aimed to clarify the risk factors for hepatic steatosis in the two subtypes of PA, comparing the status of hepatic steatosis in each of these subtypes. This was a retrospective observational study. We enrolled patients with an aldosterone producing adenoma (APA) (n = 33) or idiopathic hyperaldosteronism (IHA) (n = 56). Hepatic fat content was evaluated using the ratio of liver to spleen (L/S) X-ray attenuation on unenhanced computed tomography. L/S ratio <1.0 was utilized for assessing as hepatic steatosis. Age, sex distribution, visceral fat percentage (VF%), and visceral fat area (VFA) did not differ between patients with the two PA subtypes. The percentages of patients with L/S ratio <1.0 was not different between the two subtypes (APA: 21.2 % (7/33) vs. IHA: 19.6 % (11/56), p = 1.00). In both subtypes, the L/S ratio negatively correlated with VF% (APA: r = -0.66, p < 0.001; IHA: r = -0.66, p < 0.001) and with VFA (APA: r = -0.44, p < 0.01; IHA: r = -0.37, p < 0.01). The status of hepatic steatosis, evaluated using L/S ratio, did not differ between patients with APA or IHA. Hepatic steatosis was affected by the amount of visceral fat.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-8959
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1507/endocrj.EJ19-0600