Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure

Tada, Atsushi; Omote, Kazunori; Nagai, Toshiyuki; Honda, Yasuyuki; Nakano, Hiroki; Honda, Satoshi; Iwakami, Naotsugu; Hamatani, Yasuhiro; Nakai, Michikazu; Nishimura, Kunihiro; Asaumi, Yasuhide; Aiba, Takeshi; Noguchi, Teruo; Kusano, Kengo; Yokoyama, Hiroyuki; Yasuda, Satoshi; Ogawa, Hisao; Anzai, Toshihisa

Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure

Tada, Atsushi; Omote, Kazunori; Nagai, Toshiyuki et al.

Journal of clinical medicine, 2020, 9(7), 2219

Permalink : https://hdl.handle.net/2115/79261

このアイテムのアクセス数:535件（2026-08-19 23:15 集計）

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https://doi.org/10.3390/jcm9072219			32

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アクセス権	open access
URI	https://hdl.handle.net/2115/79261
タイトル	Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure
著者	Tada, Atsushi ; Omote, Kazunori ; Nagai, Toshiyuki ; Honda, Yasuyuki ; Nakano, Hiroki ; Honda, Satoshi ; Iwakami, Naotsugu ; Hamatani, Yasuhiro ; Nakai, Michikazu ; Nishimura, Kunihiro ; Asaumi, Yasuhide ; Aiba, Takeshi ; Noguchi, Teruo ; Kusano, Kengo ; Yokoyama, Hiroyuki ; Yasuda, Satoshi ; Ogawa, Hisao ; Anzai, Toshihisa
著者名 Tada, Atsushi
e-Rad_Researcher 10827744 著者名 Omote, Kazunori
e-Rad_Researcher 00528218 著者名 Nagai, Toshiyuki
著者名 Honda, Yasuyuki
著者名 Nakano, Hiroki
著者名 Honda, Satoshi
著者名 Iwakami, Naotsugu
著者名 Hamatani, Yasuhiro
著者名 Nakai, Michikazu
著者名 Nishimura, Kunihiro
著者名 Asaumi, Yasuhide
著者名 Aiba, Takeshi
著者名 Noguchi, Teruo
著者名 Kusano, Kengo
著者名 Yokoyama, Hiroyuki
著者名 Yasuda, Satoshi
著者名 Ogawa, Hisao
e-Rad_Researcher 60232089 著者名 Anzai, Toshihisa
言語	英語
キーワード	acute heart failure
	hospital-acquired pneumonia
	prognosis
発行日	2020-07
出版者	MDPI
収録物名	Journal of clinical medicine
巻(号)	9(7)
ページ	2219
抄録	The prognostic impact of hospital-acquired pneumonia (HAP) in acute heart failure (AHF) patients have not been fully elucidated. We evaluated 776 consecutive hospitalized AHF patients. The primary in-hospital outcomes were all-cause death and worsening heart failure (WHF), while the outcome following discharge was all-cause death. The clinical diagnosis of HAP was based on clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Patients with HAP had a significantly higher incidence of in-hospital death (12% vs. 1%,p< 0.001), WHF during the hospitalization (28% vs. 7%,p< 0.001), and longer length of hospital stay (p= 0.003) than those without. Among patients who survived at discharge, during a median follow-up period of 741 (interquartile range 422-1000) days, the incidence of all-cause death was significantly higher in patients with HAP than in those without (p< 0.001). In the multivariable Cox regression, HAP development was independently associated with all-cause death after discharge (HR [hazard ratio] 1.86, 95%CI [confidence interval] 1.08-3.19). Furthermore, older age (OR [odds ratio] 1.04, 95%CI 1.01-1.08), male sex (OR 2.21, 95%CI 1.14-4.28), and higher serum white blood cell count (OR 1.18, 95%CI 1.09-1.29) and serum C-reactive protein (OR 1.08, 95%CI 1.01-1.06) were independently associated with HAP development. In hospitalized patients with AHF, HAP development was associated with worse clinical outcomes, suggesting the importance of prevention and early screening for HAP.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/jcm9072219