Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction

Kaibara, Takuma; Kondo, Eiji; Matsuoka, Masatake; Iwasaki, Koji; Onodera, Tomohiro; Momma, Daisuke; Seito, Naoki; Mikami, Susumu; Iwasaki, Norimasa

Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction

Kaibara, Takuma; Kondo, Eiji; Matsuoka, Masatake et al.

BMC musculoskeletal disorders, 2020, 21(1), 494

Permalink : https://hdl.handle.net/2115/79264

このアイテムのアクセス数:661件（2026-08-27 03:21 集計）

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https://doi.org/10.1186/s12891-020-03531-8			14

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アクセス権	open access
URI	https://hdl.handle.net/2115/79264
タイトル	Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction
著者	Kaibara, Takuma ; Kondo, Eiji ; Matsuoka, Masatake ; Iwasaki, Koji ; Onodera, Tomohiro ; Momma, Daisuke ; Seito, Naoki ; Mikami, Susumu ; Iwasaki, Norimasa
著者名 Kaibara, Takuma
e-Rad_Researcher 60374724 著者名 Kondo, Eiji
e-Rad_Researcher 70816066 著者名 Matsuoka, Masatake
e-Rad_Researcher 40771895 著者名 Iwasaki, Koji
e-Rad_Researcher 70547174 著者名 Onodera, Tomohiro
e-Rad_Researcher 50779866 著者名 Momma, Daisuke
著者名 Seito, Naoki
著者名 Mikami, Susumu
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
キーワード	Osteochondral defect
	Autologous chondrocyte implantation
	Atelocollagen
	Anterior cruciate ligament reconstruction
	Orthopedics
	Knee
発行日	2020-07-27
出版者	BioMed Central
収録物名	BMC musculoskeletal disorders
巻(号)	21(1)
ページ	494
抄録	Background Articular surface damage commonly associated with rupture of the anterior cruciate ligament (ACL). Large osteochondral defect, which consists of a severe depression fracture and a large cartilage defect, need to be treated due to deformation of the articular surface as it can impact the clinical outcome of ACL reconstruction. Although autologous chondrocyte implantation is one of the useful options in such cases, it can be questioned whether the reconstruction of the ACL and osteochondral defect should be performed in one procedure alone. Case presentation We report a case of a 38-year-old male with a deep depression fracture extending to the edge of the lateral femoral condyle associated with ACL injury after twisting his right knee while skiing. The patient was successfully treated with tissue-engineered cartilage transplantation covered by the periosteum with an iliac bone graft combined with anatomic double-bundle ACL reconstruction. Histopathological examination of the transplanted cartilage taken at second-look arthroscopy showed a cartilage-like tissue in the middle to deep zone in which the extracellular matrix was largely stained with Safranin O. The patient was able to return to his previous level of skiing activity without any experience of knee pain. Magnetic resonance imaging at 4 years after surgery showed that the graft integrated to the border zone and subchondral bone. The operated knee showed negative Lachman test and had a full range of motion. Conclusions To our knowledge, this is the first report of anatomic double-bundle ACL reconstruction with tissue-engineered cartilage transplantation and an iliac bone graft to restore the lateral edge of the femoral condyle.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12891-020-03531-8