Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water

Matsuya, Yusuke; Kai, Takeshi; Yoshii, Yuji; Yachi, Yoshie; Naijo, Shingo; Date, Hiroyuki; Sato, Tatsuhiko

Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water

Matsuya, Yusuke; Kai, Takeshi; Yoshii, Yuji et al.

Journal of Applied Physics, 2019, 126(12), 124701

Permalink : https://hdl.handle.net/2115/79314

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/79314
タイトル	Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water
著者	Matsuya, Yusuke ; Kai, Takeshi ; Yoshii, Yuji ; Yachi, Yoshie ; Naijo, Shingo ; Date, Hiroyuki ; Sato, Tatsuhiko
e-Rad_Researcher 20826929 著者名 Matsuya, Yusuke
e-Rad_Researcher 70403037 著者名 Kai, Takeshi
著者名 Yoshii, Yuji
著者名 Yachi, Yoshie
著者名 Naijo, Shingo
e-Rad_Researcher 10197600 著者名 Date, Hiroyuki
e-Rad_Researcher 30354707 著者名 Sato, Tatsuhiko
言語	英語
発行日	2019-09-28
出版者	American Institute of Physics (AIP)
収録物名	Journal of Applied Physics
巻(号)	126(12)
ページ	124701
抄録	DNA strand breaks are induced in cells mainly composed of liquid water along ionizing radiation tracks. For estimating DNA strand break yields, track structures for electrons in liquid water in Monte Carlo simulations are of great importance; however, detailed simulations to obtain both energy deposition and free radical reaction to DNA are time-consuming processes. Here, we present a simple model for estimating yields of single- and double-strand breaks (SSB, DSB, and DSB/SSB ratio) based only on spatial patterns of inelastic interactions (i.e., ionization and electronic excitation) generated by electrons, which are evaluated by the track structure mode of Particle and Heavy Ion Transport code System without analyzing the production and diffusion of free radicals. In the present model, the number of events per track and that of a pair composed of two events within 3.4 nm (10 base pairs) were stochastically sampled for calculating SSB and DSB yields. The results calculated by this model agree well with other simulations and experimental data on the DSB yield and the DSB/SSB ratio for monoenergetic electron irradiation. This model also demonstrates the relative biological effectiveness at the DSB endpoint for various photon irradiations, indicating that the spatial pattern composed of ionization and electronic excitation without physicochemical and chemical stages is sufficient to obtain the impact of electrons on the initial DNA strand break induction.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Matsuya, Yusuke, et al. "Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water." Journal of Applied Physics 126.12 (2019): 124701 and may be found at https://doi.org/10.1063/1.5115519
PISSN	0021-8979
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1063/1.5115519