The role of Mediator and Little Elongation Complex in transcription termination

Takahashi, Hidehisa; Ranjan, Amol; Chen, Shiyuan; Suzuki, Hidefumi; Shibata, Mio; Hirose, Tomonori; Hirose, Hiroko; Sasaki, Kazunori; Abe, Ryota; Chen, Kai; He, Yanfeng; Zhang, Ying; Takigawa, Ichigaku; Tsukiyama, Tadasuke; Watanabe, Masashi; Fujii, Satoshi; Iida, Midori; Yamamoto, Junichi; Yamaguchi, Yuki; Suzuki, Yutaka; Matsumoto, Masaki; Nakayama, Keiichi I.; Washburn, Michael P.; Saraf, Anita; Florens, Laurence; Sato, Shigeo; Tomomori-Sato, Chieri; Conaway, Ronald C.; Conaway, Joan W.; Hatakeyama, Shigetsugu

The role of Mediator and Little Elongation Complex in transcription termination

Takahashi, Hidehisa; Ranjan, Amol; Chen, Shiyuan et al.

Nature communications, 2020, 11(1), 1063

Permalink : https://hdl.handle.net/2115/79483

このアイテムのアクセス数:657件（2026-08-24 18:02 集計）

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https://doi.org/10.1038/s41467-020-14849-1			9

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アクセス権	open access
URI	https://hdl.handle.net/2115/79483
タイトル	The role of Mediator and Little Elongation Complex in transcription termination
著者	Takahashi, Hidehisa ; Ranjan, Amol ; Chen, Shiyuan ; Suzuki, Hidefumi ; Shibata, Mio ; Hirose, Tomonori ; Hirose, Hiroko ; Sasaki, Kazunori ; Abe, Ryota ; Chen, Kai ; He, Yanfeng ; Zhang, Ying ; Takigawa, Ichigaku ; Tsukiyama, Tadasuke ; Watanabe, Masashi ; Fujii, Satoshi ; Iida, Midori ; Yamamoto, Junichi ; Yamaguchi, Yuki ; Suzuki, Yutaka ; Matsumoto, Masaki ; Nakayama, Keiichi I. ; Washburn, Michael P. ; Saraf, Anita ; Florens, Laurence ; Sato, Shigeo ; Tomomori-Sato, Chieri ; Conaway, Ronald C. ; Conaway, Joan W. ; Hatakeyama, Shigetsugu
e-Rad_Researcher 30423544 著者名 Takahashi, Hidehisa
著者名 Ranjan, Amol
著者名 Chen, Shiyuan
e-Rad_Researcher 00793770 著者名 Suzuki, Hidefumi
著者名 Shibata, Mio
著者名 Hirose, Tomonori
著者名 Hirose, Hiroko
著者名 Sasaki, Kazunori
著者名 Abe, Ryota
著者名 Chen, Kai
著者名 He, Yanfeng
著者名 Zhang, Ying
e-Rad_Researcher 10374597 著者名 Takigawa, Ichigaku
e-Rad_Researcher 20399819 著者名 Tsukiyama, Tadasuke
e-Rad_Researcher 10632424 著者名 Watanabe, Masashi
著者名 Fujii, Satoshi
著者名 Iida, Midori
e-Rad_Researcher 40748472 著者名 Yamamoto, Junichi
著者名 Yamaguchi, Yuki
e-Rad_Researcher 40323646 著者名 Suzuki, Yutaka
e-Rad_Researcher 60380531 著者名 Matsumoto, Masaki
著者名 Nakayama, Keiichi I.
著者名 Washburn, Michael P.
著者名 Saraf, Anita
著者名 Florens, Laurence
著者名 Sato, Shigeo
著者名 Tomomori-Sato, Chieri
著者名 Conaway, Ronald C.
著者名 Conaway, Joan W.
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
発行日	2020-02-26
出版者	Nature Publishing Group
収録物名	Nature communications
巻(号)	11(1)
ページ	1063
抄録	Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we provide evidence that MED26 recruits LEC to modulate transcription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replication-dependent histone (RDH) at Cajal bodies. Our findings indicate that LEC recruited by MED26 promotes efficient transcription termination by Pol II through interaction with CBC-ARS2 and NELF/DSIF, and promotes 3' end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2041-1723
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41467-020-14849-1