Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke

Kawabori, Masahito; Shichinohe, Hideo; Kuroda, Satoshi et al.

International Journal of Molecular Sciences, 2020, 21(19), 7380

Permalink : https://hdl.handle.net/2115/79552

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/79552
タイトル
Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke
著者
Kawabori, Masahito ; Shichinohe, Hideo ; Kuroda, Satoshi ; Houkin, Kiyohiro
e-Rad_Researcher
50399870
著者名
Kawabori, Masahito
e-Rad_Researcher
80374479
著者名
Shichinohe, Hideo
e-Rad_Researcher
10301904
著者名
Kuroda, Satoshi
e-Rad_Researcher
90229146
著者名
Houkin, Kiyohiro
言語
英語
キーワード
stem cell
regenerative medicine
ischemic stroke
clinical trials
transplantation
発行日
2020
出版者
Molecular Diversity Preservation International
収録物名
International Journal of Molecular Sciences
巻(号)
21(19)
ページ
7380
抄録
Despite recent developments in innovative treatment strategies, stroke remains one of the leading causes of death and disability worldwide. Stem cell therapy is currently attracting much attention due to its potential for exerting significant therapeutic effects on stroke patients. Various types of cells, including bone marrow mononuclear cells, bone marrow/adipose-derived stem/stromal cells, umbilical cord blood cells, neural stem cells, and olfactory ensheathing cells have enhanced neurological outcomes in animal stroke models. These stem cells have also been tested via clinical trials involving stroke patients. In this article, the authors review potential molecular mechanisms underlying neural recovery associated with stem cell treatment, as well as recent advances in stem cell therapy, with particular reference to clinical trials and future prospects for such therapy in treating stroke.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
権利情報
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
EISSN
1422-0067
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/ijms21197380