Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

Fathoni, Imam; Petitbois, Julie G.; Alarif, Walied M.; Abdel-Lateff, Ahmed; Al-Lihaibi, Sultan S.; Yoshimura, Erina; Nogata, Yasuyuki; Vairappan, Charles S.; Sholikhah, Eti Nurwening; Okino, Tatsufumi

Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

Fathoni, Imam; Petitbois, Julie G.; Alarif, Walied M. et al.

Molecules, 2020, 25(17), 3986

Permalink : https://hdl.handle.net/2115/79611

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アクセス権	open access
URI	https://hdl.handle.net/2115/79611
タイトル	Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera
著者	Fathoni, Imam ; Petitbois, Julie G. ; Alarif, Walied M. ; Abdel-Lateff, Ahmed ; Al-Lihaibi, Sultan S. ; Yoshimura, Erina ; Nogata, Yasuyuki ; Vairappan, Charles S. ; Sholikhah, Eti Nurwening ; Okino, Tatsufumi
著者名 Fathoni, Imam
著者名 Petitbois, Julie G.
著者名 Alarif, Walied M.
著者名 Abdel-Lateff, Ahmed
著者名 Al-Lihaibi, Sultan S.
著者名 Yoshimura, Erina
e-Rad_Researcher 10371535 著者名 Nogata, Yasuyuki
著者名 Vairappan, Charles S.
著者名 Sholikhah, Eti Nurwening
e-Rad_Researcher 30280910 著者名 Okino, Tatsufumi
言語	英語
キーワード	cyanobacteria
	antiplasmodial
	cytotoxic
	antifouling
	Moorea
	Okeania
発行日	2020-09-01
出版者	MDPI
収録物名	Molecules
巻(号)	25(17)
ページ	3986
抄録	Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a MalaysianMoorea bouilloniiand a Red SeaOkeaniasp.: lyngbyabellins G (1), O (2), P (3), H (4), A (7), 27-deoxylyngbyabellin A (5), and homohydroxydolabellin (6). This study indicated that lyngbyabellins displayed cytotoxicity, antimalarial, and antifouling activities. The isolated compounds were tested for cytotoxic effect against human breast cancer cells (MCF7), for antifouling activity againstAmphibalanus amphitritebarnacle larvae, and for antiplasmodial effect towardsPlasmodium falciparum. Lyngbyabellins A and G displayed potent antiplasmodial effect againstPlasmodium, whereas homohydroxydolabellin showed moderate effect. For antifouling activity, the side chain decreases the activity slightly, but the essential feature is the acyclic structure. As previously reported, the acyclic lyngbyabellins are less cytotoxic than the corresponding cyclic ones, and the side chain increases cytotoxicity. This study revealed that lyngbyabellins, despite being cytotoxic agents as previously reported, also exhibit antimalarial and antifouling activities. The unique chemical structures and functionalities of lyngbyabellin play an essential role in their biological activities.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1420-3049
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/molecules25173986