open access

https://hdl.handle.net/2115/79616

Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp(3))-H Activation of Thioamides

英語

2019-10-28

American Chemical Society

Organometallics

38(20)

3921-3926

Enantioselective C-H functionalization reactions using trivalent group 9 metals (Co, Rh, Ir) have been investigated mainly on the basis of the development of well-designed chiral cyclopentadienyl (Cp) ligands. Although it has recently been demonstrated that chiral carboxylic acids combined with achiral Cp-type ligands can enable highly enantioselective C-H functionalization reactions, the structural diversity of the applied chiral acids remains limited. Here, we report that chiral 2-aryl ferrocene carboxylic acids, which are easily obtained from diastereoselective ortho lithiation and Suzuki-Miyaura coupling, can serve as external chiral sources for the Cp*Co-III-catalyzed enantioselective C(sp(3))-H amidation of alpha-aryl thioamides using dioxazolones.

学術雑誌論文

Accepted Manuscript

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organometallics, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.organomet.9b00407.

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