Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies : multicentre randomized clinical trial

Kamachi, H.; Homma, S.; Kawamura, H.; Yoshida, T.; Ohno, Y.; Ichikawa, N.; Yokota, R.; Funakoshi, T.; Maeda, Y.; Takahashi, N.; Amano, T.; Taketomi, A.

Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies : multicentre randomized clinical trial

Kamachi, H.; Homma, S.; Kawamura, H. et al.

BJS Open, 2020, 4(5), 804-810

Permalink : https://hdl.handle.net/2115/79628

このアイテムのアクセス数:662件（2026-10-23 08:39 集計）

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https://doi.org/10.1002/bjs5.50323			45

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アクセス権	open access
URI	https://hdl.handle.net/2115/79628
タイトル	Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies : multicentre randomized clinical trial
著者	Kamachi, H. ; Homma, S. ; Kawamura, H. ; Yoshida, T. ; Ohno, Y. ; Ichikawa, N. ; Yokota, R. ; Funakoshi, T. ; Maeda, Y. ; Takahashi, N. ; Amano, T. ; Taketomi, A.
e-Rad_Researcher 60374237 著者名 Kamachi, H.
著者名 Homma, S.
著者名 Kawamura, H.
著者名 Yoshida, T.
著者名 Ohno, Y.
著者名 Ichikawa, N.
著者名 Yokota, R.
著者名 Funakoshi, T.
著者名 Maeda, Y.
著者名 Takahashi, N.
著者名 Amano, T.
e-Rad_Researcher 70363364 著者名 Taketomi, A.
言語	英語
発行日	2020-10
出版者	John Wiley & Sons
収録物名	BJS Open
巻(号)	4(5)
ページ	804-810
抄録	Background: The role of antithrombotic chemoprophylaxis in prevention of venous thromboembolism (VTE) in laparoscopic surgery for gastric and colorectal malignancies is unknown. This study compared the addition of enoxaparin following intermittent pneumatic compression (IPC) with IPC alone in patients undergoing laparoscopic surgery for gastrointestinal malignancy. Methods: In this multicentre RCT, eligible patients were older than 40 years and had a WHO performance status of 0 or 1. Exclusion criteria were prescription of antiplatelet or anticoagulant drugs and history of VTE. Patients were allocated to IPC or to ICP with enoxaparin in a 1 : 1 ratio. Stratification factors included sex, location of cancer, age 61 years and over, and institution. Enoxaparin was administered on days 1-7 after surgery. Primary outcome was VTE, evaluated by multidetector CT on day 7. Results: Of 448 patients randomized, 208 in the IPC group and 182 in the IPC with enoxaparin group were evaluated. VTE occurred in ten patients (4.8 per cent) in the IPC group and six (3.3 per cent) in the IPC with enoxaparin group (P = 0.453). Proximal deep vein thrombosis and/or pulmonary embolism occurred in seven patients (3.4 per cent) in the IPC group and one patient (0.5 per cent) in the IPC with enoxaparin group (P = 0.050). All VTE events were asymptomatic and non-fatal. Bleeding occurred in 11 of 202 patients in the IPC with enoxaparin group, and one patient needed a transfusion. All bleeding events were managed by discontinuation of the drug. Conclusion: IPC with enoxaparin after laparoscopic surgery for gastric and colorectal malignancies did not reduce the rate of VTE.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2474-9842
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/bjs5.50323