Decreased electrodermal activity in patients with epilepsy

Horinouchi, Toru; Sakurai, Kotaro; Munekata, Nagisa; Kurita, Tsugiko; Takeda, Youji; Kusumi, Ichiro

Decreased electrodermal activity in patients with epilepsy

Horinouchi, Toru; Sakurai, Kotaro; Munekata, Nagisa et al.

Epilepsy and behavior, 2019, 100, UNSP 106517

Permalink : https://hdl.handle.net/2115/79653

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アクセス権	open access
URI	https://hdl.handle.net/2115/79653
タイトル	Decreased electrodermal activity in patients with epilepsy
著者	Horinouchi, Toru ; Sakurai, Kotaro ; Munekata, Nagisa ; Kurita, Tsugiko ; Takeda, Youji ; Kusumi, Ichiro
e-Rad_Researcher 80796029 著者名 Horinouchi, Toru
著者名 Sakurai, Kotaro
著者名 Munekata, Nagisa
著者名 Kurita, Tsugiko
著者名 Takeda, Youji
e-Rad_Researcher 30250426 著者名 Kusumi, Ichiro
言語	英語
キーワード	Electrodennal activity
	Biofeedback therapy
	Seizure numbers
	Noninvasive
	Galvanic skin response
	Intractable epilepsy
発行日	2019-11
出版者	Elsevier
収録物名	Epilepsy and behavior
巻(号)	100
ページ	UNSP 106517
抄録	Objective: Biofeedback therapy using electrodermal activity (EDA) is a new noninvasive therapy for intractable epilepsy. However, the characteristics of EDA in patients with epilepsy are little known; therefore, we assessed the EDA characteristics in patients with epilepsy. Methods: A cross-sectional observational study was conducted in 22 patients with epilepsy and 24 healthy individuals. We collected information on demographic characteristics, EDA, and state anxiety from both groups, and epilepsy diagnosis, seizure number per month, disease duration, and number of antiepileptic drugs (AED) from the epilepsy group. A wristband device was used to measure resting EDA from both wrists for 10 min under controlled temperature and humidity. We compared the EDA levels between the epilepsy group and the control group and examined correlations between EDA and epilepsy-associated factors in the epilepsy group. Results: A decreasing trend in EDA was observed during the first 1 min from the start of the measurement in 22 patients with epilepsy (with or without seizures) compared with healthy controls (P = 0.12). However, a significant decrease in EDA was found in 18 patients with epilepsy with seizures compared with healthy controls (- 0.48 versus -0.26; P = 0.036). Furthermore, seizure frequency showed a significant inverse correlation with EDA in the epilepsy group (p =-0.50, P = 0.016). However, neither disease duration nor the number of drugs prescribed correlated with EDA in the epilepsy group. Significance: Marginally decreased EDA was observed in patients with epilepsy, and significantly decreased EDA was found in patients with a higher seizure frequency. The present findings shed light on the appropriateness of EDA-biofeedback therapy in epilepsy. (C) 2019 Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1525-5050
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.yebeh.2019.106517