Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones : The Hokkaido birth cohort study

Itoh, Sachiko; Baba, Toshiaki; Yuasa, Motoyuki et al.

Environmental Research, 2018, 167, 583-590

Permalink : https://hdl.handle.net/2115/79664

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/79664
タイトル
Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones : The Hokkaido birth cohort study
その他のタイトル
Hydroxylated-PCB exposure and thyroid hormones
著者
Itoh, Sachiko ; Baba, Toshiaki ; Yuasa, Motoyuki ; Miyashita, Chihiro ; Kobayashi, Sumitaka ; Araki, Atsuko ; Sasaki, Seiko ; Kajiwara, Jumboku ; Hori, Tsuguhide ; Todaka, Takashi ; Fujikura, Kaori ; Nakajima, Sonomi ; Kato, Shizue ; Kishi, Reiko
e-Rad_Researcher
90580936
著者名
Itoh, Sachiko
著者名
Baba, Toshiaki
e-Rad_Researcher
30463748
著者名
Yuasa, Motoyuki
e-Rad_Researcher
70632389
著者名
Miyashita, Chihiro
e-Rad_Researcher
10733371
著者名
Kobayashi, Sumitaka
e-Rad_Researcher
00619885
著者名
Araki, Atsuko
e-Rad_Researcher
30448831
著者名
Sasaki, Seiko
著者名
Kajiwara, Jumboku
著者名
Hori, Tsuguhide
著者名
Todaka, Takashi
著者名
Fujikura, Kaori
著者名
Nakajima, Sonomi
著者名
Kato, Shizue
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
言語
英語
キーワード
Prenatal exposure
Hydroxylated polychlorinated biphenyls
Prospective cohort study
Thyroid hormone
Structural equation modeling
発行日
2018-11
出版者
Elsevier
収録物名
Environmental Research
巻(号)
167
ページ
583-590
抄録
Background: Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for thyroid hormones (TH) is limited, and the underlying mechanism remains unknown. Objectives: We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and maternal and neonatal TH levels, taking the maternal-fetal TH transfer into account. Methods: In this prospective birth cohort (the "Hokkaido study") we included 222 mother-neonate pairs. We measured five OH-PCB isomers in maternal serum samples either during pregnancy or within 5 days of delivery. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from maternal blood samples at an early gestational stage (median; 11.1 weeks) and from heel prick samples of neonates between 4 and 7 days after birth. Multiple linear regression analysis and structural equation modeling (SEM) were performed to investigate the associations between maternal OH-PCB and maternal and neonatal TH levels. Results: Median concentration of ΣOH-PCBs was 25.37 pg/g wet weight. The predominant isomer was 4-OH-CB187, followed by 4-OH-CB146+3-OH-CB153. In the fully adjusted linear regression analysis, maternal ΣOH-PCBs was positively associated with maternal FT4, and 4-OH-CB187 was positively associated with both maternal and neonatal FT4 levels. Maternal OH-PCBs showed no significant association with TSH among mothers and neonates. Path analysis indicated the indirect pathway from 4-OH-CB187 exposure to increased neonatal FT4, via maternal THs and neonatal TSH. Conclusions: These findings suggest that maternal exposure to OH-PCBs during pregnancy may increase both maternal and neonatal FT4 levels. Neonatal FT4 is presumed to be increased by prenatal 4-OH-CB187 indirectly, and this process may be mediated by maternal THs and neonatal TSH.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0013-9351
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.envres.2018.08.027