Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease

Naganuma, Ryoji; Yabe, Ichiro; Takeuchi, Megumi; Morishita, Kirari; Nakane, Shingo; Takase, Ryoken; Takahashi-Iwata, Ikuko; Matsushima, Masaaki; Otsuki, Mika; Shiraishi, Hideaki; Sasaki, Hidenao

Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease

Naganuma, Ryoji; Yabe, Ichiro; Takeuchi, Megumi et al.

PLoS ONE, 2020, 15(9), e0232808

Permalink : https://hdl.handle.net/2115/79689

このアイテムのアクセス数:642件（2026-08-13 10:04 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1371/journal.pone.0232808			16

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/79689
タイトル	Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease
著者	Naganuma, Ryoji ; Yabe, Ichiro ; Takeuchi, Megumi ; Morishita, Kirari ; Nakane, Shingo ; Takase, Ryoken ; Takahashi-Iwata, Ikuko ; Matsushima, Masaaki ; Otsuki, Mika ; Shiraishi, Hideaki ; Sasaki, Hidenao
著者名 Naganuma, Ryoji
e-Rad_Researcher 60372273 著者名 Yabe, Ichiro
著者名 Takeuchi, Megumi
著者名 Morishita, Kirari
著者名 Nakane, Shingo
著者名 Takase, Ryoken
著者名 Takahashi-Iwata, Ikuko
著者名 Matsushima, Masaaki
e-Rad_Researcher 10372880 著者名 Otsuki, Mika
e-Rad_Researcher 80374411 著者名 Shiraishi, Hideaki
e-Rad_Researcher 80281806 著者名 Sasaki, Hidenao
言語	英語
発行日	2020-09-17
出版者	PLOS
収録物名	PLoS ONE
巻(号)	15(9)
ページ	e0232808
抄録	Studies on evoked responses in Parkinson's disease (PD) may be useful for elucidating the etiology and quantitative evaluation of PD. However, in previous studies, the association between evoked responses and detailed motor symptoms or cognitive functions has not been clear. This study investigated the characteristics of the visual (VEF), auditory (AEF), and somatosensory (SEF) evoked magnetic fields in patients with Parkinson's disease (PD), and the correlations between evoked fields and the patient's clinical characteristics, motor symptoms, and cognitive functions. Twenty patients with PD and 10 healthy controls (HCs) were recruited as participants. We recorded VEF, AEF, and SEF, collected clinical characteristics, performed physical examinations, and administered 10 cognitive tests. We investigated differences in the latencies of the evoked fields between patients with PD and HCs. We also evaluated the correlation of the latencies with motor symptoms and cognitive functioning. There were significant differences between the two groups in 6 of the cognitive tests, all of which suggested mild cognitive impairment in patients with PD. The latencies of the VEF N75m, P100m, N145m, AEF P50m, P100m, and SEF P60m components were greater in the patients with PD than in the HCs. The latencies mainly correlated with medication and motor symptoms, less so with cognitive tests, with some elements of the correlations remaining significant after Bonferroni correction. In conclusion, the latencies of the VEF, AEF, and SEF were greater in PD patients than in HCs and were mainly correlated with medication and motor symptoms rather than cognitive functioning. Findings from this study suggest that evoked fields may reflect basal ganglia functioning and are candidates for assessing motor symptoms or the therapeutic effects of medication in patients with PD.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0232808