Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period

Yamasaki, Shojiro; Kimura, Goh; Koizumi, Kazunari; Dai, Ning; Ketema, Rahel Mesfin; Tomihara, Tomomi; Ueno, Yukako; Ohno, Yuki; Sato, Shin; Kurasaki, Masaaki; Hosokawa, Toshiyuki; Saito, Takeshi

Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period

Yamasaki, Shojiro; Kimura, Goh; Koizumi, Kazunari et al.

Food & Nutrition Research, 2020, 64, 5231

Permalink : https://hdl.handle.net/2115/79757

このアイテムのアクセス数:638件（2026-08-09 17:27 集計）

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https://doi.org/10.29219/fnr.v64.5231			29

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アクセス権	open access
URI	https://hdl.handle.net/2115/79757
タイトル	Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period
著者	Yamasaki, Shojiro ; Kimura, Goh ; Koizumi, Kazunari ; Dai, Ning ; Ketema, Rahel Mesfin ; Tomihara, Tomomi ; Ueno, Yukako ; Ohno, Yuki ; Sato, Shin ; Kurasaki, Masaaki ; Hosokawa, Toshiyuki ; Saito, Takeshi
著者名 Yamasaki, Shojiro
著者名 Kimura, Goh
著者名 Koizumi, Kazunari
著者名 Dai, Ning
著者名 Ketema, Rahel Mesfin
著者名 Tomihara, Tomomi
著者名 Ueno, Yukako
著者名 Ohno, Yuki
e-Rad_Researcher 40310099 著者名 Sato, Shin
e-Rad_Researcher 80161727 著者名 Kurasaki, Masaaki
e-Rad_Researcher 00157025 著者名 Hosokawa, Toshiyuki
e-Rad_Researcher 40153811 著者名 Saito, Takeshi
言語	英語
キーワード	maternal supplements
	high-fat diet
	green tea extract
	adult offspring
	hepatic fat accumulation
発行日	2020-10-05
出版者	Swedish Nutrition Foundation
収録物名	Food & Nutrition Research
巻(号)	64
ページ	5231
抄録	Background: Maternal lipid intake in the early postnatal period has a long-term effect on the possibility of fatty liver formation in children; besides, the importance of lipid consumption during lactation for children's health has been suggested. Green tea extract (GTE) contains abundant catechins, and it has been reported to improve lipid metabolism and prevent fatty liver. Objective: The aim of this study was to examine the effects of maternal GTE intake during lactation on hepatic lipid accumulation in adult male rats exposed to a continuous high-fat (HF) diet from the foetal period. Methods: Pregnant Wistar rats received diets containing 13% (control-fat, CON) or 45% (high-fat, HF) fat. CON-fed mothers received the same diet during lactation, whereas HF-fed mothers received either HF diet alone or HF diet supplemented with 0.24% GTE. At weaning, male offspring were divided into three groups, i.e. CON/CON/CON, HF/HF/HF (HF-offspring) or HF/HF+GTE/HF (GTE-offspring), and were fed until 51 weeks. Results: A significant hepatic triglyceride (Tg) accumulation was observed in the HF-offspring when compared with the other offspring. This is presumed to be caused by the promotion of Tg synthesis derived from exogenous fatty acid due to a significant increase in diacylglycerol O-acyltransferase 1 and a decrease in Tg -expenditure caused by decreasing microsomal triglyceride transfer protein (MTTP) and long-chain acyl-CoA dehydrogenase. On the other hand, attenuated hepatic Tg accumulation was observed in the GTE-offspring. The levels of the hepatic lipid metabolism-related enzymes were improved to the same level as the CON-offspring, and particularly, MTTP was significantly increased as compared with the HF-offspring. Conclusion: This study indicates the potential protective effects of maternal GTE intake during lactation on HF diet-induced hepatic lipid accumulation in adult male rat offspring and the possible underlying mechanisms.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1654-6628
EISSN	1654-661X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.29219/fnr.v64.5231