Flazin as a Promising Nrf2 Pathway Activator

Fuda, Hirotoshi; Miyanaga, Satoshi; Furukawa, Takayuki; Umetsu, Satomi; Joko, Sae; Roan, Yuning; Suzuki, Hirotaka; Hui, Shu-Ping; Watanabe, Mitsugu; Chiba, Hitoshi

Flazin as a Promising Nrf2 Pathway Activator

Fuda, Hirotoshi; Miyanaga, Satoshi; Furukawa, Takayuki et al.

Journal of Agricultural and Food Chemistry, 2019, 67(46), 12844-12853

Permalink : https://hdl.handle.net/2115/79777

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アクセス権	open access
URI	https://hdl.handle.net/2115/79777
タイトル	Flazin as a Promising Nrf2 Pathway Activator
著者	Fuda, Hirotoshi ; Miyanaga, Satoshi ; Furukawa, Takayuki ; Umetsu, Satomi ; Joko, Sae ; Roan, Yuning ; Suzuki, Hirotaka ; Hui, Shu-Ping ; Watanabe, Mitsugu ; Chiba, Hitoshi
e-Rad_Researcher 60576172 著者名 Fuda, Hirotoshi
著者名 Miyanaga, Satoshi
e-Rad_Researcher 30754642 著者名 Furukawa, Takayuki
著者名 Umetsu, Satomi
著者名 Joko, Sae
著者名 Roan, Yuning
著者名 Suzuki, Hirotaka
e-Rad_Researcher 90337030 著者名 Hui, Shu-Ping
著者名 Watanabe, Mitsugu
e-Rad_Researcher 70197622 著者名 Chiba, Hitoshi
言語	英語
キーワード	Keap1
	Nrf2
	hepatocyte
	phase II enzyme
	flazin
	ORAC
発行日	2019-11-20
出版者	American Chemical Society
収録物名	Journal of Agricultural and Food Chemistry
巻(号)	67(46)
ページ	12844-12853
抄録	Flazin is a beta-carboline-derived alkaloid found in Japanese fermented foods. Here, the potential of flazin as an antioxidant food was studied with particular reference to its effect on the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) system in human hepatocytes (C3A). Flazin and flazin analogues including the decarboxylated derivative perlolyrine were chemically synthesized and compared with each other and with chlorogenic acid and curcumin. Among these compounds, flazin showed the lowest cytotoxicity (IC50 < 500 mu M) and the highest capacity to activate the Keap1-Nrf2 system. It provided the largest (>3-fold of the control) cytoprotection ability against a pro-oxidant, although its radical absorbance capacity was relatively low. Flazin increased the expressions of Nrf2-dependent phase II enzyme genes and their products (NQO1, GSTP, and GSH proteins). The strong cytoprotection ability of flazin associated with low log P (0-3) is shared by sulforaphane and 3,5-dihydroxy-4-methoxybenzyl alcohol, suggesting the potential value of flazin and flazin-rich foods for the prevention of oxidation-related health disorders.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of agricultural and food chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.9b04600.
PISSN	0021-8561
関連情報	PMID 31668063
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.jafc.9b04600