Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation

Deepak, Hadya Virupaksha; Swamy, Mahadeva M. M.; Murai, Yuta; Suga, Yoshiko; Anetai, Masaki; Yo, Takuro; Kuragano, Masahiro; Uwai, Koji; Tokuraku, Kiyotaka; Monde, Kenji

Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation

Deepak, Hadya Virupaksha; Swamy, Mahadeva M. M.; Murai, Yuta et al.

Molecules, 2020, 25(18), 4077

Permalink : https://hdl.handle.net/2115/79844

このアイテムのアクセス数:639件（2026-10-09 11:32 集計）

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https://doi.org/10.3390/molecules25184077			23

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/79844
タイトル	Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation
著者	Deepak, Hadya Virupaksha ; Swamy, Mahadeva M. M. ; Murai, Yuta ; Suga, Yoshiko ; Anetai, Masaki ; Yo, Takuro ; Kuragano, Masahiro ; Uwai, Koji ; Tokuraku, Kiyotaka ; Monde, Kenji
著者名 Deepak, Hadya Virupaksha
著者名 Swamy, Mahadeva M. M.
著者名 Murai, Yuta
著者名 Suga, Yoshiko
著者名 Anetai, Masaki
著者名 Yo, Takuro
著者名 Kuragano, Masahiro
著者名 Uwai, Koji
著者名 Tokuraku, Kiyotaka
e-Rad_Researcher 40210207 著者名 Monde, Kenji
言語	英語
キーワード	daurichromenic acid
	sphingomyelin synthase
	amyloid β
	dual inhibitor
	lipid-related disease
発行日	2020-09
出版者	MDPI
収録物名	Molecules
巻(号)	25(18)
ページ	4077
抄録	Species of the genus Rhododendron have been used in traditional Chinese medicine, with the medicinal herb "Manshanfong" used as an expectorant and for the treatment of acute bronchitis. Daurichromenic acid (DCA), a constituent of Rhododendron dauricum, is a meroterpenoid with antibacterial, anti-HIV, and anti-inflammatory activities. However, the mechanisms underlying these pharmacologic activities are poorly understood. To develop new drugs based on DCA, more information is required regarding its interactions with biomolecules. The present study showed that DCA inhibits the activity of the enzyme sphingomyelin synthase, with an IC50 of 4 mu M. The structure-activity relationships between DCA and sphingomyelin synthase were evaluated using derivatives and cyclized hongoquercin A. In addition, DCA was found to inhibit amyloid beta aggregation. These results may help in the design of effective drugs based on DCA.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/molecules25184077