Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer

Nakano, Shintaro; Komatsu, Yoshito; Kawamoto, Yasuyuki et al.

Medicine, 2020, 99(39), e22250

Permalink : https://hdl.handle.net/2115/79870

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https://doi.org/10.1097/MD.0000000000022250     23

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アクセス権
open access
URI
https://hdl.handle.net/2115/79870
タイトル
Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer
著者
Nakano, Shintaro ; Komatsu, Yoshito ; Kawamoto, Yasuyuki ; Saito, Rika ; Ito, Ken ; Nakatsumi, Hiroshi ; Yuki, Satoshi ; Sakamoto, Naoya
著者名
Nakano, Shintaro
e-Rad_Researcher
60333598
著者名
Komatsu, Yoshito
e-Rad_Researcher
60755601
著者名
Kawamoto, Yasuyuki
著者名
Saito, Rika
著者名
Ito, Ken
e-Rad_Researcher
50735157
著者名
Nakatsumi, Hiroshi
著者名
Yuki, Satoshi
e-Rad_Researcher
10334418
著者名
Sakamoto, Naoya
言語
英語
キーワード
antibiotics
gemcitabine plus nab-paclitaxel
pancreatic cancer
progression-free survival
retrospective cohort
発行日
2020-09-25
出版者
Lippincott Williams & Wilkins (LWW)
収録物名
Medicine
巻(号)
99(39)
ページ
e22250
抄録
It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP. We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hospital. Ninety-nine patients were eligible for the study. Thirty-seven used antibiotics (U) and 62 did not use antibiotics (NU) during GnP therapy. In the U group, 15 patients used beta-lactam antibiotics, 21 used new quinolones, and 1 used carbapenem. The median progression-free survival was 5.8 and 2.7 months (hazards ratio [HR] .602, 95% confidence interval [CI] .391-.928,P = .022) and the median overall survival was 11.0 and 8.4 months (HR .768, 95% CI .491-1.202,P = .248) in the U and not use antibiotics groups, respectively. Antibiotic use (HR .489, 95% CI .287-.832,P = .008) and locally advanced pancreatic cancer (HR 1.808, 95% CI 1.051-3.112,P = .032) were independent prognostic factors for progression-free survival. Antibiotic use was associated with a higher efficacy of GnP, and therefore, it may be employed as a novel treatment strategy.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial 4.0 International
PISSN
0025-7974
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1097/MD.0000000000022250