Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone

Hata, Hironobu; Kitao, Tomoka; Sato, Jun; Asaka, Takuya; Imamachi, Kenji; Miyakoshi, Masaaki; Hirata, Kenji; Magota, Keiichi; Munakata, Yamato; Shiga, Tohru; Yamazaki, Yutaka; Kitagawa, Yoshimasa

Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone

Hata, Hironobu; Kitao, Tomoka; Sato, Jun et al.

Scientific reports, 2020, 10(1), 17461

Permalink : https://hdl.handle.net/2115/79885

このアイテムのアクセス数:658件（2026-08-10 01:20 集計）

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https://doi.org/10.1038/s41598-020-74335-y			8

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アクセス権	open access
URI	https://hdl.handle.net/2115/79885
タイトル	Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone
著者	Hata, Hironobu ; Kitao, Tomoka ; Sato, Jun ; Asaka, Takuya ; Imamachi, Kenji ; Miyakoshi, Masaaki ; Hirata, Kenji ; Magota, Keiichi ; Munakata, Yamato ; Shiga, Tohru ; Yamazaki, Yutaka ; Kitagawa, Yoshimasa
e-Rad_Researcher 70450830 著者名 Hata, Hironobu
著者名 Kitao, Tomoka
e-Rad_Researcher 60319069 著者名 Sato, Jun
e-Rad_Researcher 80637265 著者名 Asaka, Takuya
e-Rad_Researcher 40779873 著者名 Imamachi, Kenji
著者名 Miyakoshi, Masaaki
e-Rad_Researcher 30431365 著者名 Hirata, Kenji
e-Rad_Researcher 20636419 著者名 Magota, Keiichi
著者名 Munakata, Yamato
e-Rad_Researcher 80374495 著者名 Shiga, Tohru
e-Rad_Researcher 90250464 著者名 Yamazaki, Yutaka
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
言語	英語
発行日	2020-10-15
出版者	Nature Research
収録物名	Scientific reports
巻(号)	10(1)
ページ	17461
抄録	Effects of long-term bisphosphonate (BP) administration on the metabolism of healthy bone and the concomitant changes in imaging are unclear. Hence, we aimed to retrospectively investigate the effects of long-term BP administration on the intact parietal bone using the standardised uptake value (SUV) derived from single photon emission computed tomography (SPECT). We enrolled 29 patients who had odontogenic infection, osteoporosis, bone metastasis cancer, or rheumatoid arthritis, and classified them into BP-naive: A (14 patients) and BP-treated: B,<4 years (7 patients) and C,<greater than or equal to>4 years (8 patients) groups. We measured the maximum bilateral SUV (SUVmax) of the parietal bone using quantitative bone SPECT software. There were significant differences in the duration of BP administration and SUVmax of the parietal bone among the diseases (P<0.0001 and P=0.0086, respectively). There was a positive correlation between the duration of BP administration and SUVmax of the parietal bone (r(s)=0.65, P=0.0002). The SUVmax was significantly different between A and B (P=0.02) and between A and C (P=0.0024) groups. This is the first report on the correlation between long-term BP administration and the SUVmax of the parietal bone using the quantitative bone SPECT analysis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-020-74335-y