Blood-brain barrier permeability analysis of plant ceramides

Eguchi, Koichi; Mikami, Daisuke; Sun, Hui et al.

PLoS ONE, 2020, 15(11), e0241640

Permalink : https://hdl.handle.net/2115/79968

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https://doi.org/10.1371/journal.pone.0241640     21

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アクセス権
open access
URI
https://hdl.handle.net/2115/79968
タイトル
Blood-brain barrier permeability analysis of plant ceramides
著者
Eguchi, Koichi ; Mikami, Daisuke ; Sun, Hui ; Tsumita, Takuya ; Takahashi, Kaori ; Mukai, Katsuyuki ; Yuyama, Kohei ; Igarashi, Yasuyuki
著者名
Eguchi, Koichi
著者名
Mikami, Daisuke
著者名
Sun, Hui
著者名
Tsumita, Takuya
著者名
Takahashi, Kaori
著者名
Mukai, Katsuyuki
e-Rad_Researcher
80415546
著者名
Yuyama, Kohei
著者名
Igarashi, Yasuyuki
言語
英語
発行日
2020-11-02
出版者
PLOS
収録物名
PLoS ONE
巻(号)
15(11)
ページ
e0241640
抄録
Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate a variety of cell functions. In plants, ceramides are mostly present in a glucosylated glucosylceramide (GlcCer) form. We previously showed that oral administration of konjac-derived GlcCer to a mouse model of Alzheimer's disease reduced brain amyloid-beta and amyloid plaques. Dietary plant GlcCer compounds are absorbed as ceramides, but it is unclear whether they can cross the blood-brain barrier (BBB). Herein, we evaluated the BBB permeability of synthetic plant-type ceramides (4, 8-sphingadienine, d18:2) using mouse and BBB cell culture models, and found that they could permeate the BBB both in vivo and in vitro. In addition, administrated ceramides were partially metabolized to other sphingolipid species, namely sphingomyelin (SM) and GlcCer, while crossing the BBB. Thus, plant ceramides can cross the BBB, suggesting that ceramides and their metabolites might affect brain functions.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1932-6203
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1371/journal.pone.0241640