Unique Running Pattern and Mucosal Morphology Found in the Colon of Cotton Rats

Chuluunbaatar, Tsolmon; Ichii, Osamu; Nakamura, Teppei; Irie, Takao; Namba, Takashi; Islam, Md Rashedul; Otani, Yuki; Masum, Md Abdul; Okamatsu-Ogura, Yuko; Elewa, Yaser Hosny Ali; Kon, Yasuhiro

Unique Running Pattern and Mucosal Morphology Found in the Colon of Cotton Rats

Chuluunbaatar, Tsolmon; Ichii, Osamu; Nakamura, Teppei et al.

Frontiers in physiology, 2020, 11, 587214

Permalink : https://hdl.handle.net/2115/80079

このアイテムのアクセス数:1,018件（2026-10-10 22:40 集計）

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https://doi.org/10.3389/fphys.2020.587214			29

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アクセス権	open access
URI	https://hdl.handle.net/2115/80079
タイトル	Unique Running Pattern and Mucosal Morphology Found in the Colon of Cotton Rats
著者	Chuluunbaatar, Tsolmon ; Ichii, Osamu ; Nakamura, Teppei ; Irie, Takao ; Namba, Takashi ; Islam, Md Rashedul ; Otani, Yuki ; Masum, Md Abdul ; Okamatsu-Ogura, Yuko ; Elewa, Yaser Hosny Ali ; Kon, Yasuhiro
著者名 Chuluunbaatar, Tsolmon
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 80786773 著者名 Nakamura, Teppei
著者名 Irie, Takao
著者名 Namba, Takashi
著者名 Islam, Md Rashedul
著者名 Otani, Yuki
著者名 Masum, Md Abdul
著者名 Okamatsu-Ogura, Yuko
著者名 Elewa, Yaser Hosny Ali
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	cotton rat
	morphology
	large intestine
	colon
	longitudinal fold
	sex difference
発行日	2020-10-26
出版者	Frontiers Media
収録物名	Frontiers in physiology
巻(号)	11
ページ	587214
抄録	Cotton rats are one of the experimental rodents used for testing different infectious and non-infectious diseases, including gastrointestinal tract pathology. However, their intestinal morphological characteristics are still poorly understood. Here, we clarified the anatomical and histological characteristics of the cecum and ascending colon (AC) of young (1-3-month old), adult (4-6-month old), and old (10-12-month old) cotton rats. The large intestine (LI) in cotton rats is composed of the cecum, AC, transverse and descending colons, and rectum, and is similar to that of other mammals. The AC begins with a double or triple spiral loop-like flexure (SLLF) and ends with a coupled horseshoe-like flexure (HSLF). A single longitudinal mucosal fold (SLMF) was found at the beginning of the AC along the mesentery line and developed with age. Furthermore, the SLMF contained several lymphatic nodules (LNs), indicating their role in digestive and immunological functions. Small and large protuberant LNs were found in the cecum and SLLF, respectively, whereas thin and flat LNs were observed in the HSLF and transverse colon, respectively. Regarding sex-related differences, adult females had a significantly longer AC with a higher number of SLLFs compared to males. The SLMF length and LN number were also longer and higher, respectively, in adult females compared to adult males. These are crucial findings, indicating the presence of sex-related differences in the morphology of the LI in cotton rats, and ours is the first study to discover a sex difference in the mammalian LI lining. Our study clarified the unique morphology of the LI in cotton rats, which could serve as the principal model for elucidating species-specific digestive tract functions and gastrointestinal disorders.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1664-042X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3389/fphys.2020.587214