Effect of setup error in the single-isocenter technique on stereotactic radiosurgery for multiple brain metastases

Nakano, Hisashi; Tanabe, Satoshi; Utsunomiya, Satoru; Yamada, Takumi; Sasamoto, Ryuta; Nakano, Toshimichi; Saito, Hirotake; Takizawa, Takeshi; Sakai, Hironori; Ohta, Atsushi; Abe, Eisuke; Kaidu, Motoki; Aoyama, Hidefumi

Effect of setup error in the single-isocenter technique on stereotactic radiosurgery for multiple brain metastases

Nakano, Hisashi; Tanabe, Satoshi; Utsunomiya, Satoru et al.

Journal of applied clinical medical physics, 2020, 21(12), 155-165

Permalink : https://hdl.handle.net/2115/80097

このアイテムのアクセス数:671件（2026-08-09 23:28 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/80097
タイトル	Effect of setup error in the single-isocenter technique on stereotactic radiosurgery for multiple brain metastases
著者	Nakano, Hisashi ; Tanabe, Satoshi ; Utsunomiya, Satoru ; Yamada, Takumi ; Sasamoto, Ryuta ; Nakano, Toshimichi ; Saito, Hirotake ; Takizawa, Takeshi ; Sakai, Hironori ; Ohta, Atsushi ; Abe, Eisuke ; Kaidu, Motoki ; Aoyama, Hidefumi
著者名 Nakano, Hisashi
著者名 Tanabe, Satoshi
著者名 Utsunomiya, Satoru
著者名 Yamada, Takumi
著者名 Sasamoto, Ryuta
著者名 Nakano, Toshimichi
著者名 Saito, Hirotake
著者名 Takizawa, Takeshi
著者名 Sakai, Hironori
著者名 Ohta, Atsushi
著者名 Abe, Eisuke
著者名 Kaidu, Motoki
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
言語	英語
キーワード	multiple brain metastases
	setup error
	single-isocenter technique
	stereotactic radiosurgery
	volumetric modulated arc therapy
発行日	2020-12
出版者	John Wiley & Sons
収録物名	Journal of applied clinical medical physics
巻(号)	21(12)
ページ	155-165
抄録	In conventional stereotactic radiosurgery (SRS), treatment of multiple brain metastases using multiple isocenters is time-consuming resulting in long dose delivery times for patients. A single-isocenter technique has been developed which enables the simultaneous irradiation of multiple targets at one isocenter. This technique requires accurate positioning of the patient to ensure optimal dose coverage. We evaluated the effect of six degrees of freedom (6DoF) setup errors in patient setups on SRS dose distributions for multiple brain metastases using a single-isocenter technique. We used simulated spherical gross tumor volumes (GTVs) with diameters ranging from 1.0 to 3.0 cm. The distance from the isocenter to the target's center was varied from 0 to 15 cm. We created dose distributions so that each target was entirely covered by 100% of the prescribed dose. The target's position vectors were rotated from 0 degrees-2.0 degrees and translated from 0-1.0 mm with respect to the three axes in space. The reduction in dose coverage for the targets for each setup error was calculated and compared with zero setup error. The calculated margins for the GTV necessary to satisfy the tolerance values for loss of GTV coverage of 3% to 10% were defined as coverage-based margins. In addition, the maximum isocenter to target distance for different 6DoF setup errors was calculated to satisfy the tolerance values. The dose coverage reduction and coverage-based margins increased as the target diameter decreased, and the distance and 6DoF setup error increased. An increase in setup error when a single-isocenter technique is used may increase the risk of missing the tumor; this risk increases with increasing distance from the isocenter and decreasing tumor size.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1526-9914
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/acm2.13081