Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study

Nakamura, Akinobu; Miyoshi, Hideaki; Ukawa, Shigekazu; Nakamura, Koshi; Nakagawa, Takafumi; Terauchi, Yasuo; Tamakoshi, Akiko; Atsumi, Tatsuya

Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study

Nakamura, Akinobu; Miyoshi, Hideaki; Ukawa, Shigekazu et al.

Journal of Diabetes Investigation, 2021, 12(1), 63-66

Permalink : https://hdl.handle.net/2115/80120

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アクセス権	open access
URI	https://hdl.handle.net/2115/80120
タイトル	Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study
著者	Nakamura, Akinobu ; Miyoshi, Hideaki ; Ukawa, Shigekazu ; Nakamura, Koshi ; Nakagawa, Takafumi ; Terauchi, Yasuo ; Tamakoshi, Akiko ; Atsumi, Tatsuya
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
e-Rad_Researcher 40706751 著者名 Ukawa, Shigekazu
e-Rad_Researcher 80422898 著者名 Nakamura, Koshi
著者名 Nakagawa, Takafumi
e-Rad_Researcher 40359609 著者名 Terauchi, Yasuo
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	adiponectin
	pancreatic beta-cells
	proinsulin
発行日	2021-01
出版者	John Wiley & Sons
収録物名	Journal of Diabetes Investigation
巻(号)	12(1)
ページ	63-66
抄録	Serum high‐molecular‐weight adiponectin (HMWA) has a positive correlation with insulin secretion in a Japanese population. To validate this correlation, we investigated the correlation between serum HMWA and proinsulin, a marker of beta‐cell dysfunction, in this population. 488 participants (53.9% females) aged 35 to 79 years without having oral hypoglycemic agents and/or insulin were enrolled. HMWA was significantly and inversely correlated with proinsulin adjusted for age and sex (partial regression coefficient: β= -0.37; 95% confidence interval: -0.46 to -0.28). When the participants were divided into two groups by median values of body mass index (23.2 kg/m2), serum insulin (4.3 μU/mL), or homeostasis model assessment of insulin resistance (1.0), similar inverse correlations were observed adjusted for age and sex in both groups. Our results demonstrated that the HMWA level was inversely correlated with the proinsulin level in a general Japanese population.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2040-1116
EISSN	2040-1124
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jdi.13323