Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

Khidkhan, Kraisiri; Mizukawa, Hazuki; Ikenaka, Yoshinori; Nakayama, Shouta M. M.; Nomiyama, Kei; Yokoyama, Nozomu; Ichii, Osamu; Takiguchi, Mitsuyoshi; Tanabe, Shinsuke; Ishizuka, Mayumi

Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

Khidkhan, Kraisiri; Mizukawa, Hazuki; Ikenaka, Yoshinori et al.

Journal of veterinary medical science, 2020, 82(7), 978-982

Permalink : https://hdl.handle.net/2115/80142

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https://doi.org/10.1292/jvms.20-0140			10

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アクセス権	open access
URI	https://hdl.handle.net/2115/80142
タイトル	Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)
著者	Khidkhan, Kraisiri ; Mizukawa, Hazuki ; Ikenaka, Yoshinori ; Nakayama, Shouta M. M. ; Nomiyama, Kei ; Yokoyama, Nozomu ; Ichii, Osamu ; Takiguchi, Mitsuyoshi ; Tanabe, Shinsuke ; Ishizuka, Mayumi
著者名 Khidkhan, Kraisiri
e-Rad_Researcher 60612661 著者名 Mizukawa, Hazuki
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
e-Rad_Researcher 30512686 著者名 Nomiyama, Kei
著者名 Yokoyama, Nozomu
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
e-Rad_Researcher 60116952 著者名 Tanabe, Shinsuke
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	BDE-209
	cat
	chronic exposure
	cytochrome P450
	mRNA expression
発行日	2020-07-31
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	82(7)
ページ	978-982
抄録	The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1-CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers ( PBDEs) in cat.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.20-0140