Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage

Shimohata, Nobuyuki; Echigo, Ryosuke; Karatsu, Kensuke et al.

Journal of veterinary medical science, 2020, 82(5), 566-570

Permalink : https://hdl.handle.net/2115/80175

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https://doi.org/10.1292/jvms.19-0201     11

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/80175
タイトル
Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage
著者
Shimohata, Nobuyuki ; Echigo, Ryosuke ; Karatsu, Kensuke ; Uchikawa, Saori ; Suzuki, Shigeki ; Chung, Ung-il ; Sasaki, Nobuo ; Mochizuki, Manabu
著者名
Shimohata, Nobuyuki
著者名
Echigo, Ryosuke
著者名
Karatsu, Kensuke
著者名
Uchikawa, Saori
著者名
Suzuki, Shigeki
著者名
Chung, Ung-il
著者名
Sasaki, Nobuo
著者名
Mochizuki, Manabu
言語
英語
キーワード
blood clotting
coagulation
fibrinolysis
subarachnoid hemorrhage
trehalose
発行日
2020-05
出版者
公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名
Journal of veterinary medical science
巻(号)
82(5)
ページ
566-570
抄録
Subarachnoid hemorrhage (SAH) frequently results in several serious complications, such as cerebral vasospasm. We previously reported the effect of trehalose on vasospasm, inflammatory responses, and lipid peroxidation induced by blood exposure. Herein, to further elucidate the mechanism of action of trehalose, we investigated whether or not post-administration of trehalose can directly influence blood clotting in the cistern. As a result of trehalose injection after the onset of experimental SAH, blood clotting around the basilar artery was clearly inhibited. We also found that trehalose positively impacted coagulation and fibrinolysis parameters in rat, rabbit and human plasma in vitro. These findings suggest that trehalose has suppressive effects on blood clotting in addition to vasospasm, inflammatory responses, and lipid peroxidation after SAH.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN
0916-7250
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.19-0201