Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells

Hossain, Kaniz Fatima Binte; Rahman, Md Mostafizur; Sikder, Md Tajuddin; Hosokawa, Toshiyuki; Saito, Takeshi; Kurasaki, Masaaki

Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells

Hossain, Kaniz Fatima Binte; Rahman, Md Mostafizur; Sikder, Md Tajuddin et al.

Ecotoxicology and environmental safety, 2021, 207, 111262

Permalink : https://hdl.handle.net/2115/80228

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/80228
タイトル	Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells
著者	Hossain, Kaniz Fatima Binte ; Rahman, Md Mostafizur ; Sikder, Md Tajuddin ; Hosokawa, Toshiyuki ; Saito, Takeshi ; Kurasaki, Masaaki
著者名 Hossain, Kaniz Fatima Binte
著者名 Rahman, Md Mostafizur
著者名 Sikder, Md Tajuddin
e-Rad_Researcher 00157025 著者名 Hosokawa, Toshiyuki
e-Rad_Researcher 40153811 著者名 Saito, Takeshi
e-Rad_Researcher 80161727 著者名 Kurasaki, Masaaki
言語	英語
キーワード	Oxidative stress
	Apoptosis
	Glutathione
	ERK1
	nrf2
	HO1
発行日	2021-01-01
出版者	Elsevier
収録物名	Ecotoxicology and environmental safety
巻(号)	207
ページ	111262
抄録	Mercury (Hg) in its all forms, including inorganic Hg (iHg) is an environmental contaminant due to toxicity and diseases in human. However, a little is known about the underlying mechanisms responsible for iHg toxicity. Selenium (Se) is an essential trace element, recognized as an antioxidant and protective agent against metal toxicities. The purpose of this research was to investigate ameliorations of Se counter to iHg-mediated toxicity in PC12 cells. Cytotoxic assays have been shown that iHg (5 mu M) caused oxidative stress and intrinsic apoptosis via ROS generation, oxidizing glutathione, damaging DNA, degrading cell membrane integrity, down-regulating mTOR, p-mTOR, akt and ERK1, and up-regulating cleaved caspase 3 and cytochrome c release in PC12 cells 48 h after incubation. Co-treatment of Se (5 mu M) inhibited intrinsic apoptosis and oxidative stress induced by iHg (5 mu M) via inhibiting ROS formation, boosting GPx contents, increasing reduced glutathione, limiting DNA degradation, improving cell membrane integrity, up-regulating mTOR, p-mTOR, akt, ERK1 and caspase 3, and down-regulating cleaved caspase 3 and cytochrome c leakage in PC12 cells. In conclusion, these results rec-ommended that excessive ROS generation acts a critical role in iHg-influenced oxidative stress and co-treatment of Se attenuates iHg-cytotoxicity through its antioxidant properties.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0147-6513
NCID	AA00179452
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.ecoenv.2020.111262