The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis

Sajiki, Yamato; Konnai, Satoru; Goto, Shinya; Okagawa, Tomohiro; Ohira, Kosuke; Shimakura, Honami; Maekawa, Naoya; Gondaira, Satoshi; Higuchi, Hidetoshi; Tajima, Motoshi; Hirano, Yuki; Kohara, Junko; Murata, Shiro; Ohashi, Kazuhiko

The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis

Sajiki, Yamato; Konnai, Satoru; Goto, Shinya et al.

Frontiers in veterinary science, 2020, 7, 609443

Permalink : https://hdl.handle.net/2115/80300

このアイテムのアクセス数:544件（2026-08-12 09:08 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/80300
タイトル	The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis
著者	Sajiki, Yamato ; Konnai, Satoru ; Goto, Shinya ; Okagawa, Tomohiro ; Ohira, Kosuke ; Shimakura, Honami ; Maekawa, Naoya ; Gondaira, Satoshi ; Higuchi, Hidetoshi ; Tajima, Motoshi ; Hirano, Yuki ; Kohara, Junko ; Murata, Shiro ; Ohashi, Kazuhiko
著者名 Sajiki, Yamato
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
著者名 Goto, Shinya
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
著者名 Ohira, Kosuke
著者名 Shimakura, Honami
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
著者名 Gondaira, Satoshi
著者名 Higuchi, Hidetoshi
著者名 Tajima, Motoshi
著者名 Hirano, Yuki
著者名 Kohara, Junko
e-Rad_Researcher 10579163 著者名 Murata, Shiro
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
キーワード	TGF-β
	1
	Mycoplasma bovis
	regulatory T cell
	immunosuppression
	cattle
発行日	2020-12-02
出版者	Frontiers Media
収録物名	Frontiers in veterinary science
巻(号)	7
ページ	609443
抄録	Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-beta and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4(+)CD25(high)Foxp3(+) T cells, was increased in M. bovis-infected cattle. Additionally, the plasma of M. bovis-infected cattle contained the high concentrations of TGF-beta 1, and M. bovis infection induced TGF-beta 1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-beta 1 on bovine immune cells. Treatment with TGF-beta 1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro. These results suggest that the increase in Tregs and TGF-beta 1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M. bovis infection.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3389/fvets.2020.609443