Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas

Minatogawa, Hideki; Yasuda, Koichi; Dekura, Yasuhiro; Takao, Seishin; Matsuura, Taeko; Yoshimura, Takaaki; Suzuki, Ryusuke; Yokota, Isao; Fujima, Noriyuki; Onimaru, Rikiya; Shimizu, Shinichi; Aoyama, Hidefumi; Shirato, Hiroki

Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas

Minatogawa, Hideki; Yasuda, Koichi; Dekura, Yasuhiro et al.

Journal of applied clinical medical physics, 2021, 22(1), 174-183

Permalink : https://hdl.handle.net/2115/80385

このアイテムのアクセス数:602件（2026-08-15 12:29 集計）

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https://doi.org/10.1002/acm2.13128			54

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アクセス権	open access
URI	https://hdl.handle.net/2115/80385
タイトル	Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas
著者	Minatogawa, Hideki ; Yasuda, Koichi ; Dekura, Yasuhiro ; Takao, Seishin ; Matsuura, Taeko ; Yoshimura, Takaaki ; Suzuki, Ryusuke ; Yokota, Isao ; Fujima, Noriyuki ; Onimaru, Rikiya ; Shimizu, Shinichi ; Aoyama, Hidefumi ; Shirato, Hiroki
著者名 Minatogawa, Hideki
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
著者名 Dekura, Yasuhiro
e-Rad_Researcher 10614216 著者名 Takao, Seishin
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
e-Rad_Researcher 70807742 著者名 Yoshimura, Takaaki
e-Rad_Researcher 00400052 著者名 Suzuki, Ryusuke
e-Rad_Researcher 20761414 著者名 Yokota, Isao
e-Rad_Researcher 80431360 著者名 Fujima, Noriyuki
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	adaptive radiotherapy
	dosimetric comparative study
	intensity‐modulated radiotherapy
	nasopharyngeal carcinoma
	proton beam therapy
発行日	2021-01
出版者	John Wiley & Sons
収録物名	Journal of applied clinical medical physics
巻(号)	22(1)
ページ	174-183
抄録	Purpose To investigate potential advantages of adaptive intensity-modulated proton beam therapy (A-IMPT) by comparing it to adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC). Methods Ten patients with NPC treated with A-IMXT (step and shoot approach) and concomitant chemotherapy between 2014 and 2016 were selected. In the actual treatment, 46 Gy in 23 fractions (46Gy/23Fx.) was prescribed using the initial plan and 24Gy/12Fx was prescribed using an adapted plan thereafter. New treatment planning of A-IMPT was made for the same patients using equivalent dose fractionation schedule and dose constraints. The dose volume statistics based on deformable images and dose accumulation was used in the comparison of A-IMXT with A-IMPT. Results The means of the D-mean of the right parotid gland (P < 0.001), right TM joint (P < 0.001), left TM joint (P < 0.001), oral cavity (P < 0.001), supraglottic larynx (P = 0.001), glottic larynx (P < 0.001), , middle PCM (P = 0.0371), interior PCM (P < 0.001), cricopharyngeal muscle (P = 0.03643), and thyroid gland (P = 0.00216), in A-IMPT are lower than those of A-IMXT, with statistical significance. The means of, D-0.03cc, and D-mean of each sub portion of auditory apparatus and D-30% for Eustachian tube and D-0.5cc for mastoid volume in A-IMPT are significantly lower than those of A-IMXT. The mean doses to the oral cavity, supraglottic larynx, and glottic larynx were all reduced by more than 20 Gy (RBE = 1.1). Conclusions An adaptive approach is suggested to enhance the potential benefit of IMPT compared to IMXT to reduce adverse effects for patients with NPC.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1526-9914
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/acm2.13128