Potency of an Inactivated Influenza Vaccine against a Challenge with A/Swine/Missouri/A01727926/2015 (H4N6) in Mice for Pandemic Preparedness

Hayashi, Hirotaka; Isoda, Norikazu; Bazarragchaa, Enkhbold et al.

Vaccines, 2020, 8(4), 768

Permalink : https://hdl.handle.net/2115/80396

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/80396
タイトル
Potency of an Inactivated Influenza Vaccine against a Challenge with A/Swine/Missouri/A01727926/2015 (H4N6) in Mice for Pandemic Preparedness
著者
Hayashi, Hirotaka ; Isoda, Norikazu ; Bazarragchaa, Enkhbold ; Nomura, Naoki ; Matsuno, Keita ; Okamatsu, Masatoshi ; Kida, Hiroshi ; Sakoda, Yoshihiro
著者名
Hayashi, Hirotaka
e-Rad_Researcher
80615732
著者名
Isoda, Norikazu
著者名
Bazarragchaa, Enkhbold
著者名
Nomura, Naoki
e-Rad_Researcher
40753306
著者名
Matsuno, Keita
e-Rad_Researcher
00507163
著者名
Okamatsu, Masatoshi
e-Rad_Researcher
10109506
著者名
Kida, Hiroshi
e-Rad_Researcher
40333637
著者名
Sakoda, Yoshihiro
言語
英語
キーワード
antigenicity
H4 influenza
immunogenicity
pandemic
vaccine
発行日
2020-12
出版者
MDPI
収録物名
Vaccines
巻(号)
8(4)
ページ
768
抄録
H4 influenza viruses have been isolated from birds across the world. In recent years, an H4 influenza virus infection has been confirmed in pigs. Pigs play an important role in the transmission of influenza viruses to human hosts. Therefore, it is important to develop a new vaccine in the case of an H4 influenza virus infection in humans, considering that this virus has a different antigenicity from seasonal human influenza viruses. In this study, after selecting vaccine candidate strains based on their antigenic relation to one of the pig isolates, A/swine/Missouri/A01727926/2015 (H4N6) (MO/15), an inactivated whole-particle vaccine was prepared from A/swan/Hokkaido/481102/2017 (H4N6). This vaccine showed high immunogenicity in mice, and the antibody induced by the vaccine showed high cross-reactivity to the MO/15 virus. This vaccine induced sufficient neutralizing antibodies and mitigated the effects of an MO/15 infection in a mouse model. This study is the first to suggest that an inactivated whole-particle vaccine prepared from an influenza virus isolated from wild birds is an effective countermeasure in case of a future influenza pandemic caused by the H4 influenza virus.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/vaccines8040768